Sperm–oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site †
Sign Up to like & getrecommendations! Published in 2021 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioab048
Abstract: Abstract Sperm–oocyte binding initiates an outside-in signaling event in the mouse oocyte that triggers recruitment and activation of the cytosolic protein kinase PTK2B in the cortex underlying the bound sperm. While not involved in gamete… read more here.
Keywords: ptk2b activation; cd9; sperm binding; binding site ... See more keywords
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-021-00440-9
Abstract: Background Recent studies suggest that microglia contribute to tau pathology progression in Alzheimer’s disease. Amyloid plaque accumulation transforms microglia, the primary innate immune cells in the brain, into neurodegenerative microglia (MGnD), which exhibit enhanced phagocytosis… read more here.
Keywords: propagation; tau; cd9; microscopy ... See more keywords
Tetraspanin CD9 Limits Mucosal Healing in Experimental Colitis
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01854
Abstract: Tetraspanins are a family of proteins with four transmembrane domains that associate between themselves and cluster with other partner proteins, conforming a distinct class of membrane domains, the tetraspanin-enriched microdomains (TEMs). These TEMs constitute macromolecular… read more here.
Keywords: tetraspanin cd9; cd9; role cd9; colitis ... See more keywords
CD9 Tetraspanin: A New Pathway for the Regulation of Inflammation?
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02316
Abstract: CD9 belongs to the tetraspanin superfamily. Depending on the cell type and associated molecules, CD9 has a wide variety of biological activities such as cell adhesion, motility, metastasis, growth, signal transduction, differentiation, and sperm–egg fusion.… read more here.
Keywords: cd9; inflammation cd9; regulation inflammation; cd9 tetraspanin ... See more keywords
Prognostic value and multifaceted roles of tetraspanin CD9 in cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1140738
Abstract: CD9 is a crucial regulator of cell adhesion in the immune system and plays important physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is involved in the transendothelial migration of leukocytes… read more here.
Keywords: cancer; multifaceted roles; value multifaceted; prognostic value ... See more keywords
Antimicrobial Effects of Tetraspanin CD9 Peptide against Microbiota Causing Armpit Malodour
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12020271
Abstract: Synthetic peptides, including tetraspanin CD9 peptides, are increasingly coming into focus as new treatment strategies against various organisms, including bacteria, that cause underarm odour. The use of deodorants and antiperspirants is associated with side effects.… read more here.
Keywords: cd9 peptide; underarm odour; cd9 peptides; tetraspanin cd9 ... See more keywords
CD9 and CD81 Interactions and Their Structural Modelling in Sperm Prior to Fertilization
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19041236
Abstract: Proteins CD9 and CD81 are members of the tetraspanin superfamily and were detected in mammalian sperm, where they are suspected to form an active tetraspanin web and to participate in sperm–egg membrane fusion. The importance… read more here.
Keywords: fertilization; cd9; cd9 cd81; microscopy ... See more keywords
In Vitro Characterization of Human CD24hiCD38hi Regulatory B Cells Shows CD9 Is Not a Stable Breg Cell Marker
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22094583
Abstract: Regulatory B (Breg) cells are endowed with immune suppressive functions. Various human and murine Breg subtypes have been reported. While interleukin (IL)-10 intracellular staining remains the most reliable way to identify Breg cells, this technique… read more here.
Keywords: breg cells; cd9; breg; marker ... See more keywords
Tetraspanin CD9 Expression Predicts Sentinel Node Status in Patients with Cutaneous Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094775
Abstract: The tetraspanin CD9 is considered a metastasis suppressor in many cancers, however its role is highly debated. Currently, little is known about CD9 prognostic value in cutaneous melanoma. Our aim was to analyse CD9 expression… read more here.
Keywords: cd9 expression; sentinel node; tetraspanin cd9; cutaneous melanoma ... See more keywords