Soluble CD93 is an apoptotic cell opsonin recognized by αxβ2
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847801
Abstract: Efferocytosis is essential for homeostasis and prevention of the inflammatory and autoimmune diseases resulting from apoptotic cell lysis. CD93 is a transmembrane glycoprotein previously implicated in efferocytosis, with mutations in CD93 predisposing patients to efferocytosis‐associated… read more here.
Keywords: soluble cd93; apoptotic cells; apoptotic cell; cd93 ... See more keywords
Potential of serum soluble CD93 as a biomarker for asthma in an ovalbumin-induced asthma murine model
Sign Up to like & getrecommendations! Published in 2018 at "Biomarkers"
DOI: 10.1080/1354750x.2018.1443510
Abstract: Abstract Background: CD93 is a membrane-associated glycoprotein, which can be released in a soluble form (sCD93) into the serum. CD93 has received renewed attention as a candidate biomarker of inflammation in various inflammatory and immune-mediated… read more here.
Keywords: biomarker; murine model; model; cd93 ... See more keywords
CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis
Sign Up to like & getrecommendations! Published in 2018 at "Immunology"
DOI: 10.1111/imm.12974
Abstract: Microglia and non‐professional immune cells (endothelial cells, neurons) participate in the recognition and removal of pathogens and tissue debris in the injured central nervous system through major pro‐inflammatory processes. However, the mechanisms involved in regulating… read more here.
Keywords: nervous system; central nervous; inflammation; cd93 ... See more keywords
CD93 Blockade Stabilizes Tumor Vasculature to Improve Therapy Response.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2021-113
Abstract: CD93/IGFBP7 pathway disruption normalizes tumor vasculature and increases immune infiltration. read more here.
Keywords: stabilizes tumor; blockade stabilizes; cd93 blockade; tumor vasculature ... See more keywords
CD93-Signaling Regulates Self-Renewal and Proliferation of Chronic Myeloid Leukemia Stem Cells in Mice and Humans and Might be a Promising Target for Treatment
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-127864
Abstract: Background: The introduction of BCR/ABL-specific tyrosine kinase inhibitors (TKIs) more than two decades ago revolutionized chronic myelogenous leukemia (CML) therapy. The majority of CML patients treated with TKIs obtain durable cytogenetic and molecular responses. However,… read more here.
Keywords: cml; treatment; cd93; self renewal ... See more keywords
CD93 Correlates With Immune Infiltration and Impacts Patient Immunotherapy Efficacy: A Pan-Cancer Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.817965
Abstract: Background: The clinical implementation of immune-checkpoint inhibitors (ICIs) targeting CTLA4, PD-1, and PD-L1 has revolutionized the treatment of cancer. However, the majority of patients do not derive clinical benefit. Further development is needed to optimize… read more here.
Keywords: immunotherapy; pan cancer; expression; cd93 ... See more keywords
Identify the immune characteristics and immunotherapy value of CD93 in the pan-cancer based on the public data sets
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.907182
Abstract: CD93 is a transmembrane receptor that is mainly expressed on endothelial cells. A recent study found that upregulated CD93 in tumor vessels is essential for tumor angiogenesis in several cancers. However, the underlying mechanisms are… read more here.
Keywords: value cd93; expression; immunotherapy value; cd93 ... See more keywords
Multi-omics profiling and digital image analysis reveal the potential prognostic and immunotherapeutic properties of CD93 in stomach adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.984816
Abstract: Background Recent evidence highlights the fact that immunotherapy has significantly improved patient outcomes. CD93, as a type I transmembrane glycoprotein, was correlated with tumor-associated angiogenesis; however, how CD93 correlates with immunotherapy in stomach adenocarcinoma (STAD)… read more here.
Keywords: stomach adenocarcinoma; digital image; analysis; stomach ... See more keywords
Pan-Cancer Analysis Identified CD93 as a Valuable Biomarker for Predicting Patient Prognosis and Immunotherapy Response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.793445
Abstract: Background: The rapid development of immunotherapy has significantly improved patient outcomes in recent years. CD93, a novel biomarker expressed on vascular endothelial cells, is essential for tumor angiogenesis. Recent studies have shown that CD93 is… read more here.
Keywords: biomarker; immunotherapy; pan cancer; cd93 ... See more keywords