Human CD96 Correlates to Natural Killer Cell Exhaustion and Predicts the Prognosis of Human Hepatocellular Carcinoma
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DOI: 10.1002/hep.30347
Abstract: Immune checkpoint blockade has become a promising therapeutic approach to reverse immune cell exhaustion. Coinhibitory CD96 and T‐cell immunoglobulin and ITIM domain (TIGIT), together with costimulatory CD226, bind to common ligand CD155. The balancing between… read more here.
Keywords: expression; human hepatocellular; cd96; cell exhaustion ... See more keywords
CD96 targeted antibodies need not block CD96-CD155 interactions to promote NK cell anti-metastatic activity
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2018.1424677
Abstract: ABSTRACT CD96 is a transmembrane glycoprotein Ig superfamily receptor, expressed on various T cell subsets and NK cells, that interacts with nectin and nectin-like proteins, including CD155/polio virus receptor (PVR). Here, we have compared three… read more here.
Keywords: cd96; block cd96; cd155; anti metastatic ... See more keywords
Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis
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DOI: 10.1080/2162402x.2018.1445949
Abstract: ABSTRACT Multiple non-redundant immunosuppressive pathways co-exist in the tumor microenvironment and their co-targeting can increase clinical responses. Indeed, concurrent blockade of CTLA-4 and PD-1 in patients with advanced melanoma increased clinical responses over monotherapy alone… read more here.
Keywords: tigit cd96; cd96; pdcd1 cd96; cd96 mice ... See more keywords
Targeting CD96 overcomes PD-1 blockade resistance by enhancing CD8+ TIL function in cervical cancer
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-003667
Abstract: Background Novel therapies are needed to treat recurrent and advanced cervical cancer (CC), as their prognosis remains very poor. Although therapies targeting the programmed cell death protein 1 (PD-1) pathway have been approved for CC,… read more here.
Keywords: cancer; cd8 tils; function; cd8 ... See more keywords
CD96 Downregulation Promotes the Immune Response of CD4 T Cells and Associates with Ankylosing Spondylitis
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DOI: 10.1155/2022/3946754
Abstract: Inhibitory receptors (IRs) play an indispensable role in regulating T cell activation and expansion. This study is aimed at exploring the correlation between IRs and ankylosing spondylitis (AS). Bioinformatics analysis of two datasets (GSE25101 and… read more here.
Keywords: cd96; cd96 downregulation; ankylosing spondylitis; cd4 cells ... See more keywords
CD96 Is an Immune Checkpoint That Regulates CD8+ T-cell Antitumor Function
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DOI: 10.1158/2326-6066.cir-18-0637
Abstract: The antitumor activity of anti-CD96 monotherapy depends on several host factors, including CD8+ T cells and immune signaling. Inhibition of CD96 in combination with other immune checkpoint inhibitors shows superior antitumor activity over single or… read more here.
Keywords: immune checkpoint; cd8; cd96; antitumor ... See more keywords
Fcγ receptor–mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodies
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DOI: 10.1172/jci.insight.158444
Abstract: New strategies that augment T cell responses are required to broaden the therapeutic arsenal against cancer. CD96, TIGIT, and CD226 are receptors that bind to a communal ligand, CD155, and transduce either inhibitory or activating… read more here.
Keywords: activity anti; cd96; cross linking; cd96 antibodies ... See more keywords