Validation of CD98hc as a Therapeutic Target for a Combination of Radiation and Immunotherapies in Head and Neck Squamous Cell Carcinoma
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DOI: 10.3390/cancers14071677
Abstract: Simple Summary The outcome of patients with locally advanced head and neck squamous cell carcinoma (HNSCC) has not changed for the past decade despite advances in treatment strategies. SLC3A2, which encodes CD98hc, was identified as… read more here.
Keywords: hnscc; treatment; cd98hc; combination ... See more keywords
Expression of CD98hc in Pancreatic Cancer and Its Role in Cancer Cell Behavior
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DOI: 10.7150/jca.70500
Abstract: Background: Cluster of differentiation 98 heavy chain (CD98hc) is a transmembrane protein, which functions both as a coreceptor of ß-integrins, enhancing intracellular integrin-dependent downstream signaling, and as a transporter of branched-chain and aromatic amino acids.… read more here.
Keywords: cell; pancreatic cancer; cd98hc; expression ... See more keywords
Development of a high affinity Anticalin® directed against human CD98hc for theranostic applications
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DOI: 10.7150/thno.38968
Abstract: Enhanced amino acid supply and dysregulated integrin signaling constitute two hallmarks of cancer and are pivotal for metastatic transformation of cells. In line with its function at the crossroads of both processes, overexpression of CD98hc… read more here.
Keywords: human cd98hc; affinity; cd98hc; anticalin ... See more keywords