Absence of Batf3 reveals a new dimension of cell state heterogeneity within conventional dendritic cells
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102402
Abstract: Summary Conventional dendritic cells (cDCs) are traditionally subdivided into cDC1 and cDC2 lineages. Batf3 is a cDC1-required transcription factor, and we observed that Batf3−/− mice harbor a population of cDC1-like cells co-expressing cDC2-associated surface molecules.… read more here.
Keywords: cell state; cdc2; cdc1; conventional dendritic ... See more keywords
Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.103059
Abstract: Summary Successful immune responses rely on a regulated delivery of the right signals to the right cells at the right time. Here we show that natural killer (NK) and dendritic epidermal γδ T cells (DETCs)… read more here.
Keywords: cdc1; epidermal cells; natural killer; cell ... See more keywords
Characterization and expression of DEC205 in the cDC1 and cDC2 subsets of porcine dendritic cells from spleen, tonsil, and submaxillary and mesenteric lymph nodes
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2018.02.003
Abstract: &NA; Conventional dendritic cells (cDCs) are divided into the following different subtypes: cDC1, which promotes a Th1 response, and cDC2, which stimulates a Th2 and Th17 response. These cells have not been characterized in porcine… read more here.
Keywords: cdc1 cdc2; cdc2; cdc1; dec205 ... See more keywords
cDC1 vaccines drive tumor rejection by direct presentation independently of host cDC1.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-21-0865
Abstract: As a cell-based cancer vaccine, dendritic cells (DCs), derived from peripheral blood monocytes or bone marrow (BM) treated with GM-CSF (GMDCs), were initially thought to induce antitumor immunity by presenting tumor antigens directly to host… read more here.
Keywords: anti tumor; cdc1; host cdc1; tumor ... See more keywords
Direct T-cell Presentation by cDC1: The Key Feature for Cancer Vaccine Success?
Sign Up to like & getrecommendations! Published in 2022 at "Cancer immunology research"
DOI: 10.1158/2326-6066.cir-22-0473
Abstract: In this issue of Cancer Immunology Research, Ferris and colleagues demonstrate that type 1 conventional DC (cDC1) vaccines drive tumor rejection through direct antigen presentation, without the need of endogenous cDC1. This suggests that cDC1-based… read more here.
Keywords: cdc1; cell presentation; direct cell; cancer ... See more keywords
Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1127485
Abstract: A single population of interferon-regulatory factor 8 (Irf8)-dependent conventional dendritic cell (cDC type1) is considered to be responsible for both immunogenic and tolerogenic responses depending on the surrounding cytokine milieu. Here, we challenge this concept… read more here.
Keywords: cdc1 cluster; cell; cdc1; conventional dendritic ... See more keywords