Either Rap1 or Cdc13 can protect telomeric single-stranded 3′ overhangs from degradation in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55482-3
Abstract: Telomeres, the DNA-protein structures capping the ends of linear chromosomes, are important for regulating replicative senescence and maintaining genome stability. Telomeres consist of G-rich repetitive sequences that end in a G-rich single-stranded (ss) 3′ overhang,… read more here.
Keywords: single stranded; degradation; either rap1; rap1 ... See more keywords
Molecular architecture and oligomerization of Candida glabrata Cdc13 underpin its telomeric DNA-binding and unfolding activity
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DOI: 10.1093/nar/gkac1261
Abstract: Abstract The CST complex is a key player in telomere replication and stability, which in yeast comprises Cdc13, Stn1 and Ten1. While Stn1 and Ten1 are very well conserved across species, Cdc13 does not resemble… read more here.
Keywords: molecular architecture; dna; glabrata cdc13; cdc13 ... See more keywords
Loss of Cdc13 causes genome instability by a deficiency in replication-dependent telomere capping
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DOI: 10.1371/journal.pgen.1008733
Abstract: In budding yeast, Cdc13, Stn1, and Ten1 form the telomere-binding heterotrimer CST complex. Here we investigate the role of Cdc13/CST in maintaining genome stability by using a Chr VII disome system that can generate recombinants,… read more here.
Keywords: unstable chromosomes; cdc13; replication; genome instability ... See more keywords