An overview of cdc2‐like kinase 1 (Clk1) inhibitors and their therapeutic indications
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DOI: 10.1002/med.21928
Abstract: Over the past decade, Clk1 has been identified as a promising target for the treatment of various diseases, in which deregulated alternative splicing plays a role. First small molecules targeting Clk1 are in clinical trials… read more here.
Keywords: like kinase; overview cdc2; clk1; alternative splicing ... See more keywords
CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer
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DOI: 10.1038/s41598-021-86908-6
Abstract: Dysregulation of alternative splicing is a feature of cancer, both in aetiology and progression. It occurs because of mutations in splice sites or sites that regulate splicing, or because of the altered expression and activity… read more here.
Keywords: cell; cdc2 like; prostate cancer; cancer ... See more keywords
Discovery of new Cdc2-like kinase 4 (CLK4) inhibitors via pharmacophore exploration combined with flexible docking-based ligand/receptor contact fingerprints and machine learning
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DOI: 10.1039/d2ra00136e
Abstract: Cdc2-like kinase 4 (CLK4) inhibitors are of potential therapeutic value in many diseases particularly cancer. In this study, we combined extensive ligand-based pharmacophore exploration, ligand–receptor contact fingerprints generated by flexible docking, physicochemical descriptors and machine… read more here.
Keywords: clk4; cdc2 like; ligand receptor; like kinase ... See more keywords
Structural Basis for the Selective Inhibition of Cdc2-Like Kinases by CX-4945
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DOI: 10.1155/2019/6125068
Abstract: Cdc2-like kinases (CLKs) play a crucial role in the alternative splicing of eukaryotic pre-mRNAs through the phosphorylation of serine/arginine-rich proteins (SR proteins). Dysregulation of this processes is linked with various diseases including cancers, neurodegenerative diseases,… read more here.
Keywords: structural basis; cdc2 like; clk2; basis selective ... See more keywords