The intercorrelation among CCT6A, CDC20, CCNB1, and PLK1 expressions and their clinical value in papillary thyroid carcinoma prognostication
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24609
Abstract: CCT6A promotes several carcinomas' growth and invasion in multiple ways, and it relates to CCNB1 and PLK1 through its interaction with CDC20 via protein–protein interaction bioinformatics. This study aimed to explore the intercorrelation among CCT6A,… read more here.
Keywords: cct6a cdc20; ccnb1 plk1; cdc20; intercorrelation among ... See more keywords
APCCDC20-mediated degradation of PHD3 stabilizes HIF-1a and promotes tumorigenesis in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.10.011
Abstract: CDC20 regulates cell cycle progression by targeting key substrates for destruction, but its role in hepatocellular carcinoma (HCC) tumorigenesis remains to be explored. Here, by using weighted gene co-expression network analysis (WGCNA), we identified CDC20… read more here.
Keywords: phd3; hepatocellular carcinoma; degradation; hcc ... See more keywords
PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.140
Abstract: In addition to acting as building blocks for biosynthesis, amino acids might serve as signaling regulators in various physiological and pathological processes. However, it remains unknown whether amino acid levels affect the activities of hematopoietic… read more here.
Keywords: ppm1k regulates; ppm1k; cdc20; meis1 p21 ... See more keywords
Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.03.013
Abstract: Summary During mitosis, cells must segregate the replicated copies of their genome to their daughter cells with extremely high fidelity. Segregation errors lead to an abnormal chromosome number (aneuploidy), which typically results in disease or… read more here.
Keywords: mcc; apc; cdc20; yeast ... See more keywords
The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.09.005
Abstract: In the eukaryotic cell cycle, a threshold level of cyclin B accumulation triggers the G2-to-M transition, and subsequent cyclin B destruction triggers mitotic exit. The anaphase-promoting complex/cyclosome (APC/C) is the E3 ubiquitin ligase that, together… read more here.
Keywords: transition; mechanism; cyclin; cdc20 ... See more keywords
CDC20 May Serve as a Potential Biomarker-Based Risk Score System in Predicting the Prognosis of Patients with Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/8421813
Abstract: Background The specificity and sensitivity of hepatocellular carcinoma (HCC) diagnostic markers are limited, hindering the early diagnosis and treatment of HCC patients. Therefore, improving prognostic biomarkers for patients with HCC is urgently needed. Methods HCC-related… read more here.
Keywords: hepatocellular carcinoma; may serve; cdc20; related genes ... See more keywords
PP2A‐B56 binds to Apc1 and promotes Cdc20 association with the APC/C ubiquitin ligase in mitosis
Sign Up to like & getrecommendations! Published in 2019 at "EMBO Reports"
DOI: 10.15252/embr.201948503
Abstract: Cell cycle progression and genome stability are regulated by a ubiquitin ligase, the anaphase‐promoting complex/cyclosome (APC/C). Cyclin‐dependent kinase 1 (Cdk1) has long been implicated in APC/C activation; however, the molecular mechanisms of governing this process… read more here.
Keywords: pp2a b56; ubiquitin ligase; cdc20; apc ... See more keywords
CDC20 promotes bone formation via APC/C dependent ubiquitination and degradation of p65
Sign Up to like & getrecommendations! Published in 2021 at "EMBO Reports"
DOI: 10.15252/embr.202152576
Abstract: The E3 ubiquitin ligase complex CDC20‐activated anaphase‐promoting complex/Cyclosome (APC/CCDC20) plays a critical role in governing mitotic progression by targeting key cell cycle regulators for degradation. Cell division cycle protein 20 homolog (CDC20), the co‐activator of… read more here.
Keywords: bone formation; cdc20; ubiquitination degradation; p65 ... See more keywords
Selected ideal natural ligand against TNBC by inhibiting CDC20, using bioinformatics and molecular biology.
Sign Up to like & getrecommendations! Published in 2021 at "Aging"
DOI: 10.18632/aging.203642
Abstract: OBJECT Find potential therapeutic targets of triple-negative breast cancer (TNBC) patients by bioinformatics. Screen ideal natural ligand that can bind with the potential target and inhibit it by using molecular biology. METHODS Bioinformatics and molecular… read more here.
Keywords: ideal natural; natural ligand; tnbc; biology ... See more keywords
Identification of CDC20 as a Novel Biomarker in Diagnosis and Treatment of Wilms Tumor
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2021.663054
Abstract: Objective: Wilms tumor (WT) is a common malignant solid tumor in children. Many tumor biomarkers have been reported; however, there are poorly targetable molecular mechanisms which have been defined in WT. This study aimed to… read more here.
Keywords: biomarker; analysis; cdc20; wilms tumor ... See more keywords
Biochemical, biophysical, and functional characterisation of the E3 ubiquitin ligase APC/C regulator CDC20 from Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.938688
Abstract: The Anaphase Promoting Complex (APC/C), a large cullin-RING E3-type ubiquitin ligase, constitutes the ultimate target of the Spindle Assembly Checkpoint (SAC), an intricate regulatory circuit that ensures the high fidelity of chromosome segregation in eukaryotic… read more here.
Keywords: ubiquitin ligase; biochemical biophysical; arabidopsis thaliana; cdc20 ... See more keywords