Wee1 and Cdc25: Tools, pathways, mechanisms, questions
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1302229
Abstract: How are physiological signals integrated into a biochemical switch governing cell division? Cells enter mitosis and divide due to regulated activation of the cyclin-dependent kinase Cdk1. During interphase, Cdk1 is inactive due to inhibitory phosphorylation… read more here.
Keywords: cdk1; cdc25; wee1 cdc25; cell ... See more keywords
Fluorescence fluctuation analysis reveals PpV dependent Cdc25 protein dynamics in living embryos
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008735
Abstract: The protein phosphatase Cdc25 is a key regulator of the cell cycle by activating Cdk-cyclin complexes. Cdc25 is regulated by its expression levels and post-translational mechanisms. In early Drosophila embryogenesis, Cdc25/Twine drives the fast and… read more here.
Keywords: protein; cdc25; analysis; cell cycle ... See more keywords
In Silico Identification of Small Molecules as New Cdc25 Inhibitors through the Correlation between Chemosensitivity and Protein Expression Pattern
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22073714
Abstract: The cell division cycle 25 (Cdc25) protein family plays a crucial role in controlling cell proliferation, making it an excellent target for cancer therapy. In this work, a set of small molecules were identified as… read more here.
Keywords: protein expression; cdc25; small molecules; correlation chemosensitivity ... See more keywords