MicroRNA‐99a‐5p suppresses breast cancer progression and cell‐cycle pathway through downregulating CDC25A
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26906
Abstract: In this study, we aimed to explore the association between miR‐99a‐5p and CDC25A in breast cancer and the regulatory mechanisms of miR‐99a‐5p on breast cancer. The expressions of messenger RNA and microRNAs in breast cancer… read more here.
Keywords: breast cancer; mir 99a; cancer; cell ... See more keywords
Mathematical description of the interactions of CycE/Cdk2, Cdc25A, and P27Kip1 in a core cancer subnetwork
Sign Up to like & getrecommendations! Published in 2017 at "Mathematical Methods in The Applied Sciences"
DOI: 10.1002/mma.4213
Abstract: Recent studies have shown that the initiation of human cancer is due to the malfunction of some genes (such as E2F, CycE, CycD, Cdc25A, P27Kip1, and Rb) at the R-checkpoint during the G1-to-S transition of… read more here.
Keywords: p27kip1; cancer subnetwork; cancer; cyce cdk2 ... See more keywords
FDI-6 and Olaparib Synergistically Inhibit the Growth of Pancreatic Cancer by Repressing BUB1, BRCA1 and CDC25A Signaling Pathways.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.106040
Abstract: Inducing homologous recombination (HR) deficiency is a promising strategy to broaden the indication of PARP1/2 inhibitors in pancreatic cancer treatment. In addition to inhibition kinases, repression of the transcriptional function of FOXM1 has been reported… read more here.
Keywords: olaparib synergistically; brca1; cdc25a; pancreatic cancer ... See more keywords
Small-Molecule Cdc25A Inhibitors Protect Neuronal Cells from Death Evoked by NGF Deprivation and 6-Hydroxydopamine.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00474
Abstract: Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common neurodegenerative diseases that are presently incurable. There have been reports of aberrant activation of cell cycle pathways in neurodegenerative diseases. Previously, we have… read more here.
Keywords: small molecule; death; cdc25a; ngf deprivation ... See more keywords
Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition
Sign Up to like & getrecommendations! Published in 2021 at "Cell Cycle"
DOI: 10.1080/15384101.2021.1938813
Abstract: ABSTRACT Cyclin-dependent kinase (CDK) 1 complexed with cyclin B is a driver of mitosis, while CDK2 drives S phase entry and replicon initiation. CDK2 activity increases as cells progress through S phase, and its cyclin… read more here.
Keywords: inhibition; cyclin; activation; cdc25a ... See more keywords
F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac033
Abstract: Glioblastoma is a malignant CNS tumor with an extremely poor prognosis. F-box protein 11 (FBXO11) has E3 ubiquitin ligase activity and participates in the pathogenesis of multiple tumors but the role and mechanism of FBXO11… read more here.
Keywords: aerobic glycolysis; glycolysis; cdc25a; ubiquitin degradation ... See more keywords
CDC25A inhibition suppresses cell proliferation and induces G1/S‑phase cell cycle arrest in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2023.12996
Abstract: Nasopharyngeal carcinoma (NPC) is a primary malignancy that originates from the nasopharyngeal region. It has been demonstrated that a decrease in the expression level of cell division cycle gene 25A (CDC25A) suppresses cell viability and… read more here.
Keywords: cell; cdc25a; cell cycle; cell proliferation ... See more keywords
Small molecule 2,3-DCPE induces S phase arrest by activating the ATM/ATR-Chk1-Cdc25A signaling pathway in DLD-1 colon cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Letters"
DOI: 10.3892/ol.2020.12157
Abstract: In our previous study, it was reported that 2[[3-(2,3-dichlorophenoxy)propyl]amino]ethanol (2,3-DCPE) induces apoptosis and cell cycle arrest. The current study aimed to investigate the molecular mechanism involved in 2,3-DCPE-induced S phase arrest. The results demonstrated that… read more here.
Keywords: dcpe; colon cancer; cdc25a; atm atr ... See more keywords
B7-H3 promotes the cell cycle-mediated chemoresistance of colorectal cancer cells by regulating CDC25A
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer"
DOI: 10.7150/jca.37255
Abstract: Colorectal cancer (CRC) is one of the most common malignancies, and chemoresistance is one of the key obstacles in the clinical outcome. Here, we studied the function of B7-H3 in regulating cell cycle-mediated chemoresistance in… read more here.
Keywords: colorectal cancer; cdc25a; cell cycle; chemoresistance ... See more keywords