Knockdown of MAPK14 inhibits the proliferation and migration of clear cell renal cell carcinoma by downregulating the expression of CDC25B
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2795
Abstract: Mitogen‐activated protein kinase 14 (MAPK14), which plays an important role in DNA damage and repair, is activated by various environmental stress and proinflammatory cytokines. It is highly active in a variety of tumors, acting as… read more here.
Keywords: proliferation migration; mapk14; cell; clear cell ... See more keywords
CDC25B is associated with the risk of hepatocellular carcinoma, but not related to persistent infection of hepatitis B virus in a Chinese population
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology Reports"
DOI: 10.1007/s11033-020-05408-4
Abstract: The cell division cycle 25 (CDC25) gene members, including CDC25A, CDC25B and CDC25C, are reported to be associated with several human cancers. Here, we aim to investigate the association of functional polymorphisms of CDC25 gene… read more here.
Keywords: risk; infection; hbv; chinese population ... See more keywords
Early postmortem interval estimation based on Cdc25b mRNA in rat cardiac tissue.
Sign Up to like & getrecommendations! Published in 2018 at "Legal medicine"
DOI: 10.1016/j.legalmed.2018.09.004
Abstract: PURPOSE The postmortem interval (PMI) is the amount of time that has elapsed since the time of death. Over the years, many approaches have been developed to assess PMI, but their time frame of applicability… read more here.
Keywords: postmortem interval; early postmortem; time; cdc25b ... See more keywords
MiR-27a Promotes Hemin-Induced Erythroid Differentiation of K562 Cells by Targeting CDC25B
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000488436
Abstract: Background/Aims: MicroRNAs (miRNAs) play a crucial role in erythropoiesis. MiR-23a∼27a∼24-2 clusters have been proven to take part in erythropoiesis via some proteins. CDC25B (cell division control Cdc2 phosphostase B) is also the target of mir-27a;… read more here.
Keywords: hemin induced; mir 27a; erythroid differentiation; k562 cells ... See more keywords
CDC25B is required for the metaphase I-metaphase II transition in mouse oocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.252924
Abstract: Mammalian oocytes are arrested at meiotic prophase I. The dual-specificity phosphatase CDC25B is essential for cyclin-dependent kinase 1 (CDK1) activation that drives resumption of meiosis. CDC25B reverses the inhibitory effect of the protein kinases WEE1/MYT1… read more here.
Keywords: metaphase; cdc25b oocytes; cdk1 activation; cdc25b ... See more keywords
CDC25B Inhibition by menadione: a potential new therapeutical approach.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520622666220418131935
Abstract: Gastric cancer (GC) is the fifth most common type of tumor and the third leading cause of cancer death worldwide. The evolution of gastric carcinogenesis is still poorly understood and, for this reason, preclinical research… read more here.
Keywords: potential new; cdc25b inhibition; menadione potential; cancer ... See more keywords
Dual-Specificity Phosphatase CDC25B Was Inhibited by Natural Product HB-21 Through Covalently Binding to the Active Site
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2018.00531
Abstract: Cysteine 473, within the active site of the enzyme, Cdc25B, is catalytically essential for substrate activation. The most well-reported inhibitors of Cdc25 phosphatases, especially quinone-type inhibitors, function by inducing irreversible oxidation at this active site… read more here.
Keywords: phosphatase; natural product; active site; cdc25b ... See more keywords