Skp, Cullin, F-box (SCF)-Met30 and SCF-Cdc4-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A for Chromosomal Stability in Budding Yeast
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1008597
Abstract: Restricting the localization of the histone H3 variant CENP-A (Cse4 in yeast, CID in flies) to centromeres is essential for faithful chromosome segregation. Mislocalization of CENP-A leads to chromosomal instability (CIN) in yeast, fly and… read more here.
Keywords: cse4; proteolysis; mislocalization; scf ... See more keywords
Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle
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DOI: 10.7554/elife.67390
Abstract: Kinetochores are multi-subunit protein assemblies that link chromosomes to microtubules of the mitotic and meiotic spindle. It is still poorly understood how efficient, centromere-dependent kinetochore assembly is accomplished from hundreds of individual protein building blocks… read more here.
Keywords: phospho degrons; phospho; cell cycle; cdc4 ... See more keywords