Pharmacokinetics of the Rac/Cdc42 Inhibitor MBQ-167 in Mice by Supercritical Fluid Chromatography–Tandem Mass Spectrometry
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DOI: 10.1021/acsomega.9b01641
Abstract: The Rho GTPases Rac and Cdc42 are potential targets against metastatic diseases. We characterized the small molecule MBQ-167 as an effective dual Rac/Cdc42 inhibitor that reduces HER2-type tumor growth and metastasis in mice by ∼90%.… read more here.
Keywords: rac cdc42; cdc42 inhibitor; mbq 167; supercritical fluid ... See more keywords