RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109102
Abstract: Megakaryocytes (MKs), the precursors of blood platelets, are large, polyploid cells residing mainly in the bone marrow. We have previously shown that balanced signaling of the Rho GTPases RhoA and Cdc42 is critical for correct… read more here.
Keywords: cdc42 signaling; cytoplasmic maturation; cdc42; rhoa cdc42 ... See more keywords
Regulation of Cdc42 signaling by the dopamine D2 receptor in a mouse model of Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13588
Abstract: Substantial spine loss in striatal medium spiny neurons (MSNs) and abnormal behaviors are common features of Parkinson's disease (PD). The caudate putamen (CPu) mainly contains MSNs expressing dopamine D1 receptor (dMSNs) and dopamine D2 receptor… read more here.
Keywords: dopamine receptor; d2r; spine loss; cdc42 signaling ... See more keywords
A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization
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DOI: 10.1128/mcb.00547-16
Abstract: ABSTRACT Signaling by the small GTPase Cdc42 governs a diverse set of cellular processes that contribute to tissue morphogenesis. Since these processes often require highly localized signaling, Cdc42 activity must be clustered in order to… read more here.
Keywords: signaling enterocyte; cdc42; mechanism; polarization ... See more keywords
LIS1 interacts with CLIP170 to promote tumor growth and metastasis via the Cdc42 signaling pathway in salivary gland adenoid cystic carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Oncology"
DOI: 10.3892/ijo.2022.5419
Abstract: Salivary gland adenoid cystic carcinoma (SACC) is one of the most common malignant tumors, with high aggressive potential in the oral and maxillofacial regions. Lissencephaly 1 (LIS1) is a microtubule-organizing center-associated protein that regulates the… read more here.
Keywords: metastasis; sacc; signaling pathway; cdc42 signaling ... See more keywords