Structural insights into Cdc45 function: was there a nuclease at the heart of the ancestral replisome?
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Chemistry"
DOI: 10.1016/j.bpc.2016.11.011
Abstract: The role of Cdc45 in genomic duplication has remained unclear since its initial identification as an essential replication factor. Recent structural studies of Cdc45 and the evolutionarily-related archaeal GAN and bacterial RecJ nucleases have provided… read more here.
Keywords: function nuclease; cdc45; structural insights; cdc45 function ... See more keywords
A synonymous variant in a non-canonical exon of CDC45 disrupts splicing in two affected sibs with Meier-Gorlin syndrome with craniosynostosis.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medical genetics"
DOI: 10.1016/j.ejmg.2021.104182
Abstract: Disruption of the initiation of DNA replication is significantly associated with Meier-Gorlin syndrome (MGORS), an autosomal recessive condition of reduced growth, microtia and patellar a/hypoplasia. Biallelic mutations in CDC45, a member of the pre-initiation complex… read more here.
Keywords: craniosynostosis; cdc45; exon; meier gorlin ... See more keywords
DNA replication protein Cdc45 directly interacts with PCNA via its PIP box in Leishmania donovani and the Cdc45 PIP box is essential for cell survival
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DOI: 10.1371/journal.ppat.1008190
Abstract: DNA replication protein Cdc45 is an integral part of the eukaryotic replicative helicase whose other components are the Mcm2-7 core, and GINS. We identified a PIP box motif in Leishmania donovani Cdc45. This motif is… read more here.
Keywords: pip box; replication; cdc45; leishmania ... See more keywords