Molecular Mechanism of Substrate Processing by the Cdc48 ATPase Complex
Sign Up to like & getrecommendations! Published in 2017 at "Cell"
DOI: 10.1016/j.cell.2017.04.020
Abstract: The Cdc48 ATPase and its cofactors Ufd1/Npl4 (UN) extract polyubiquitinated proteins from membranes or macromolecular complexes, but how they perform these functions is unclear. Cdc48 consists of an N-terminal domain that binds UN and two… read more here.
Keywords: cdc48 atpase; atpase; mechanism substrate; cdc48 ... See more keywords
Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aax1033
Abstract: Protein unfolding, one substrate at a time Ubiquitin marks proteins for degradation by the proteasome. However, many substrates cannot be directly degraded because they are well folded or are located in cell membranes or in… read more here.
Keywords: substrate processing; cdc48 atpase; substrate; atpase ... See more keywords