The Cdc48 Complex Alleviates the Cytotoxicity of Misfolded Proteins by Regulating Ubiquitin Homeostasis.
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DOI: 10.1016/j.celrep.2020.107898
Abstract: The accumulation of misfolded proteins is associated with multiple neurodegenerative disorders, but it remains poorly defined how this accumulation causes cytotoxicity. Here, we demonstrate that the Cdc48/p97 segregase machinery drives the clearance of ubiquitinated model… read more here.
Keywords: misfolded proteins; cdc48; cdc48 deficiency; cdc48 complex ... See more keywords