Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Cancer"
DOI: 10.1002/ijc.32900
Abstract: Cdc6 is a key replication licencing factor with a pivotal role in regulating the process of DNA replication, rendering it an important investigatory focus in tumourigenesis. Indeed, Cdc6 overexpression has been found to be a… read more here.
Keywords: subcellular localisation; senescence; pancreatic cancer; cdc6 ... See more keywords
A mechanism of origin licensing control through autoinhibition of S. cerevisiae ORC·DNA·Cdc6
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28695-w
Abstract: The coordinated action of multiple replicative helicase loading factors is needed for the licensing of replication origins prior to DNA replication. Binding of the Origin Recognition Complex (ORC) to DNA initiates the ATP-dependent recruitment of… read more here.
Keywords: dna; origin licensing; cerevisiae orc; cdc6 ... See more keywords
FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2022.0169
Abstract: Forkhead box M1 (FOXM1) is a proliferative transcription factor and plays a vital role in many cancers. However, the function and molecular mechanism of FOXM1 in esophageal squamous cell carcinoma (ESCC) remain poorly understood. Hence,… read more here.
Keywords: cell; cell carcinoma; proliferation; squamous cell ... See more keywords
Abstract 877: Protein-protein interactions in cancer: An in-silico analysis of Cdc6 interactions
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-877
Abstract: Aberrant activity of cell cycle proteins is a hallmark of cancer and therefore, cell cycle regulators are considered attractive targets in cancer therapy. One such regulator, Cell division cycle 6 (Cdc6), is a key conserved… read more here.
Keywords: cell; protein protein; cdc6 interactions; cdc6 ... See more keywords
The Effect of High CDC6 Levels on Predicting Poor Prognosis in Colorectal Cancer
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DOI: 10.1159/000519913
Abstract: Introduction: We investigated the function of cell division cycle 6 (CDC6) on the prognosis in colorectal carcinoma (CRC). Methods: CDC6 protein expression levels in 121 patients with colorectal cancer and adjacent normal mucosa were detected… read more here.
Keywords: colorectal cancer; cdc6; prognosis colorectal; expression ... See more keywords
Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.74437
Abstract: Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S phase,… read more here.
Keywords: cdc14; origin licensing; cdk1; cdc6 ... See more keywords