DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors.
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DOI: 10.1021/acschembio.7b00117
Abstract: The CDC7 kinase, by phosphorylating the MCM DNA helicase, is a key switch for DNA replication initiation. ATP competitive CDC7 inhibitors are being developed as potential anticancer agents; however how human cells respond to the… read more here.
Keywords: cdc7; kinase; dna replication; inhibition ... See more keywords