Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor
Sign Up to like & getrecommendations! Published in 2019 at "Science Advances"
DOI: 10.1126/sciadv.aav3660
Abstract: A next generation cancer drug candidate, a CDC7 inhibitor, TAK-931, was developed, which is being evaluated in clinical trials. Replication stress (RS) is a cancer hallmark; chemotherapeutic drugs targeting RS are widely used as treatments… read more here.
Keywords: potential target; selective inhibitor; inhibitor; tak 931 ... See more keywords
Abstract A093: Potential combination partners for a novel CDC7-selective Inhibitor, TAK-931
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-19-a093
Abstract: Background: Cell division cycle 7 (CDC7) is a serine/threonine kinase, which plays important roles in initiation of DNA replication. We developed a CDC7-selective inhibitor, TAK-931, designed to inhibit CDC7 activity in a time-dependent and ATP-competitive… read more here.
Keywords: potential combination; selective inhibitor; tak 931; combination ... See more keywords