Cerebrotendinous Xanthomatosis ataxia responsive to CDCA and Riluzole
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2018.04.043
Abstract: Cerebrotendinous Xanthomatosis (CTX) is a rare genetic disorder due to mutations in the CYP27A1 gene resulting in both systemic and neurologic manifestations from accumulation and deposition of cholestanol in tissues. Chenodeoxycholic Acid (CDCA) is the… read more here.
Keywords: cdca; ctx; ataxia; cdca riluzole ... See more keywords
Chenodeoxycholic acid (CDCA) protects against the LPS-induced impairment of intestinal epithelial barrier function via FXR-MLCK pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.9b03173
Abstract: Chenodeoxycholic acid (CDCA), a primary bile acid, has been demonstrated to play important roles as signaling molecule in various physiology functions. However, the role of CDCA in regulating intestinal barrier function remains largely unknown. This… read more here.
Keywords: cdca; epithelial barrier; barrier function; lps induced ... See more keywords
Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06252-6
Abstract: The gut-derived hormone Fibroblast growth factor 19 (FGF19) could regulate glucose metabolism and is induced by bile acids (BAs) through activating Farnesoid X Receptor (FXR). FGF19 was found to decrease in subjects with isolated-impaired fasting… read more here.
Keywords: cdca; fibroblast growth; impaired fasting; fgf19 ... See more keywords
Differential effects of metforminâmediated BSEP repression on pravastatin and bile acid pharmacokinetics in humans: A randomized controlled trial
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13375
Abstract: Metformin has been shown to repress transcription of the bile salt export pump (BSEP) in human primary hepatocytes. The primary objective of this study was to assess the effect of oral metformin on the human… read more here.
Keywords: cdca; metformin mediated; mediated bsep; differential effects ... See more keywords
Repression of Organic Anion Transporting Polypeptide (OATP) 1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Downregulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
Sign Up to like & getrecommendations! Published in 2022 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.122.000875
Abstract: Farnesoid X receptor (FXR) is a nuclear receptor known to markedly alter expression of major transporters and enzymes in the liver. However, its effects toward organic anion transporting polypeptides (OATP) 1B1 and 1B3 remain poorly… read more here.
Keywords: chenodeoxycholic acid; cdca; expression; cynomolgus monkeys ... See more keywords
Probiotics Play a Key Role in Alleviating Bile Acid (BA)-Induced Cytokine Release and Tight Junction (TJ) Dysfunction in Human Colonic T84 Cells
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733833
Abstract: High colonic BAs play a role in pathogenesis of diarrheal diseases in ~1% of the population. Probiotic supplements are often used to help alleviate the symptoms. We have previously reported that the primary BA, chenodeoxycholic… read more here.
Keywords: cdca; lca; t84 cells; physiology ... See more keywords
Substance P Hinders Bile Acid-Induced Hepatocellular Injury by Modulating Oxidative Stress and Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11050920
Abstract: Liver failure is an outcome of chronic liver disease caused by steatohepatitis and cholestatic injury. This study examined substance P (SP) effect on liver injury due to cholestatic stress caused by excessive bile acid (BA)… read more here.
Keywords: stress; cdca; injury; bile acid ... See more keywords
Chenodeoxycholic Acid (CDCA) Promoted Intestinal Epithelial Cell Proliferation by Regulating Cell Cycle Progression and Mitochondrial Biogenesis in IPEC-J2 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11112285
Abstract: Chenodeoxycholic acid (CDCA), a primary bile acid (BA), has been demonstrated to play an important role as a signaling molecule in various physiological functions. However, the role of CDCA in regulating intestinal epithelial cell (IEC)… read more here.
Keywords: cell; cdca; proliferation; cycle progression ... See more keywords