Uncovering the molecular identity of cardiosphere-derived cells (CDCs) by single-cell RNA sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-022-00913-y
Abstract: Cardiosphere-derived cells (CDCs) generated from human cardiac biopsies have been shown to have disease-modifying bioactivity in clinical trials. Paradoxically, CDCs’ cellular origin in the heart remains elusive. We studied the molecular identity of CDCs using… read more here.
Keywords: cells cdcs; cardiosphere derived; molecular identity; cell ... See more keywords
Characterization of encapsulated porcine Cardiosphere-Derived Cells embedded in 3D alginate matrices.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120454
Abstract: Myocardial infarction is caused by an interruption of coronary blood flow, leading to one of the main death causes worldwide. Current therapeutic approaches are palliative and not able to solve the loss of cardiac tissue.… read more here.
Keywords: alginate; characterization encapsulated; cdcs; cardiosphere derived ... See more keywords
Profiles of amino acids and biogenic amines in the plasma of Cri‐du‐Chat patients
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pharmaceutical and Biomedical Analysis"
DOI: 10.1016/j.jpba.2017.03.034
Abstract: &NA; Cri‐du‐chat syndrome (CDCS) is a rare innate disease attributed to chromosome 5p deletion characterized by a cat‐like cry, craniofacial malformation, and altered behavior of affected children. Metabolomic analysis and a chemometric approach allow description… read more here.
Keywords: amino acids; amino acid; cdcs; cri chat ... See more keywords
Carbide-derived carbon obtained via bromination of titanium carbide: Comparative analysis with chlorination and hydrogen storage studies
Sign Up to like & getrecommendations! Published in 2019 at "Microporous and Mesoporous Materials"
DOI: 10.1016/j.micromeso.2018.06.037
Abstract: Abstract Carbide-derived carbons (CDCs) are synthesized from TiC micropowder via gas phase bromination at the temperature range of 350–1150 °C. The resultant carbon materials demonstrate high specific surface areas and micropore volumes of up to 1745 m2 g−1… read more here.
Keywords: hydrogen; bromination; cdcs; carbide derived ... See more keywords
P5387CRISPR/dCas9 Activated Expression of Cardiomyocyte Differentiation Factors in CDCs in Myocardial Infarctions
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.0347
Abstract: Existing therapies against myocardial infarction (MI) involve disease management by preventing additional damage to the heart muscle. However, new treatment strategies are in greater demand, which deems to focus on restoring cardiac function by replacing… read more here.
Keywords: differentiation factors; cdcs; expression; differentiation ... See more keywords
Marginal zone B cells acquire dendritic cell functions by trogocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abf7470
Abstract: Marginal zone (MZ) B cells produce broad-spectrum antibodies that protect against infection early in life. In some instances, antibody production requires MZ B cells to display pathogen antigens bound to major histocompatibility complex class II… read more here.
Keywords: mhc; trogocytosis; cdcs; zone cells ... See more keywords
Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2021-004268
Abstract: Background Dendritic cells (DCs) are professional antigen presenting cells that initiate immune defense to pathogens and tumor cells. Human tumors contain only few DCs that mostly display a non-activated phenotype. Hence, activation of tumor-associated DCs… read more here.
Keywords: human tumor; tl8 506; cdcs; blood ... See more keywords
Novel Lymphoid Pathway of Human Plasmacytoid and Conventional Dendritic Cells
Sign Up to like & getrecommendations! Published in 2019 at "Blood"
DOI: 10.1182/blood-2019-121448
Abstract: [Introduction] Dendritic cells (DCs) play a central role in initiation and regulation of immune response. Human plasmacytoid DCs (pDCs) as well as conventional DCs (cDCs) were shown to differentiate from multi-lymphoid progenitors (MLPs) as well… read more here.
Keywords: research; cdcs; prob; research funding ... See more keywords
Prenatal diagnosis of cri-du-chat syndrome by SNP array: report of twelve cases and review of the literature
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Cytogenetics"
DOI: 10.1186/s13039-019-0462-0
Abstract: BackgroundCri-du-chat syndrome (CdCS; OMIM#123450) is a classic contiguous gene syndrome caused by chromosome 5p terminal deletion (5p-), which characterized by a high-pitched cat-like cry, developmental delay, severe psychomotor, mental retardation, and dysmorphic features in infancy.… read more here.
Keywords: chat syndrome; diagnosis; snp array; cdcs ... See more keywords
Integrated analysis of the critical region 5p15.3–p15.2 associated with cri-du-chat syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Genetics and Molecular Biology"
DOI: 10.1590/1678-4685-gmb-2018-0173
Abstract: Abstract Cri-du-chat syndrome (CdCs) is one of the most common contiguous gene syndromes, with an incidence of 1:15,000 to 1:50,000 live births. To better understand the etiology of CdCs at the molecular level, we investigated… read more here.
Keywords: region 5p15; biology; cri chat; cdcs ... See more keywords
The Immunomodulatory Signature of Extracellular Vesicles From Cardiosphere-Derived Cells: A Proteomic and miRNA Profiling
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00321
Abstract: Experimental data demonstrated that the regenerative potential and immunomodulatory capacity of cardiosphere-derived cells (CDCs) is mediated by paracrine mechanisms. In this process, extracellular vesicles derived from CDCs (EV-CDCs) are key mediators of their therapeutic effect.… read more here.
Keywords: extracellular vesicles; cdcs; immunomodulatory signature; signature extracellular ... See more keywords