Cisplatin‐resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12066
Abstract: De novo and acquired resistance to platinum therapy such as cisplatin (CDDP) is a clinical challenge in gastric cancer treatment. Aberrant expression and activation of aurora kinase A (AURKA) and eukaryotic translation initiation factor 4E… read more here.
Keywords: gastric cancer; resistance; cddp; aurora kinase ... See more keywords
Self‐Stabilized Hyaluronate Nanogel for Intracellular Codelivery of Doxorubicin and Cisplatin to Osteosarcoma
Sign Up to like & getrecommendations! Published in 2018 at "Advanced Science"
DOI: 10.1002/advs.201700821
Abstract: Abstract Osteosarcoma is one of the most serious bone malignancies with rapid speed of deterioration and low survival rate in children and teenagers. Chemotherapy is an important treatment for osteosarcoma, while the conventional small‐molecule therapeutics… read more here.
Keywords: cisplatin; osteosarcoma; self stabilized; cddp ... See more keywords
A novel circular RNA circFN1 enhances cisplatin resistance in gastric cancer via sponging miR‐182‐5p
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.29641
Abstract: Cisplatin (CDDP) is commonly used for gastric cancer (GC) chemotherapy. However, after several CDDP‐based treatment cycles, patients always acquire chemotherapy resistance, which limits the overall clinical efficacy of the treatment. Clarification of the mechanisms responsible… read more here.
Keywords: cddp resistance; circfn1; gastric cancer; cddp ... See more keywords
Intraperitoneal chemotherapy for peritoneal metastases using sustained release formula of cisplatin-incorporated gelatin hydrogel granules
Sign Up to like & getrecommendations! Published in 2019 at "Surgery Today"
DOI: 10.1007/s00595-019-01792-y
Abstract: PurposeWe previously reported the effectiveness of gelatin microspheres incorporating cisplatin in a mouse model of peritoneal metastases. In this study, we report our new complete sustained-release formula of gelatin hydrogel granules incorporating cisplatin (GHG–CDDP), which… read more here.
Keywords: cisplatin; peritoneal metastases; sustained release; cddp ... See more keywords
High spatial resolution imaging of cisplatin and Texas Red cisplatin in tumour spheroids using laser ablation isotope dilution inductively coupled plasma mass spectrometry and confocal fluorescence microscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2021.338424
Abstract: Oncology research uses different imaging techniques to provide information about the spatial distribution of the chemotherapy drugs used for the targeted tissues. Among them, laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is increasingly being… read more here.
Keywords: microscopy; fluorescence; tumour spheroids; cisplatin ... See more keywords
Anticancer agents found in environment affect Daphnia at population, individual and molecular levels.
Sign Up to like & getrecommendations! Published in 2019 at "Aquatic toxicology"
DOI: 10.1016/j.aquatox.2019.105288
Abstract: Pharmaceuticals are used in medical treatment on a large scale and as a waste contaminate freshwater ecosystems. Growing amount of so-called civilization diseases, such as different type of cancer, significantly contribute to this form of… read more here.
Keywords: anticancer agents; agents found; daphnia; cddp ... See more keywords
Altered metabolic profiles and biomarkers associated with astragaloside IV-mediated protection against cisplatin-induced acute kidney injury in rats: An HPLC-TOF/MS-based untargeted metabolomics study.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114299
Abstract: Cisplatin (CDDP)-induced acute kidney injury (AKI) limits the therapeutic use of CDDP, which urgently needs to be addressed. Our previous study demonstrated that astragaloside IV (AS IV), an active compound of the traditional Chinese herb… read more here.
Keywords: metabolism; mediated protection; cddp; cddp induced ... See more keywords
Antioxidant effect of ascorbic acid against cisplatin-induced nephrotoxicity and P-glycoprotein expression in rats.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174395
Abstract: Cisplatin (CDDP) is a highly potent anticancer drug that is widely used in the treatment of several cancers. CDDP-induced nephrotoxicity (CIN) is one of the most significant adverse effects, and oxidative stress is thought to… read more here.
Keywords: induced nephrotoxicity; antioxidant effect; ascorbic acid; cddp ... See more keywords
Hydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.107805
Abstract: Cisplatin (CDDP) is widely used as a broad-spectrum anticancer chemotherapeutic drug, often giving rise to nephrotoxicity due to the enhancement of inflammation, oxidative stress, and apoptosis. Hydroxytyrosol (HT), a representative and effective polyphenol component of… read more here.
Keywords: cklf1; apoptosis; cddp; cddp induced ... See more keywords
Radiomodifying effects of RAPTA C and CDDP on DNA strand break induction
Sign Up to like & getrecommendations! Published in 2017 at "Radiation Physics and Chemistry"
DOI: 10.1016/j.radphyschem.2017.07.015
Abstract: Abstract Experimental study is exploring combined effect of RAPTA C (Ru( η 6 -p-cymene)Cl 2 (1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine)) or CDDP (cis-diamminedichloridoplatinum(II)) and radiation on the DNA damage. When irradiating plasmid DNA in solution with free molecules, no… read more here.
Keywords: dna damage; dna; radiomodifying effects; cddp ... See more keywords
Synergistic Therapy for Cervical Cancer by Codelivery of Cisplatin and JQ1 Inhibiting Plk1-Mutant Trp53 Axis.
Sign Up to like & getrecommendations! Published in 2021 at "Nano letters"
DOI: 10.1021/acs.nanolett.0c04402
Abstract: JQ1, a specific inhibitor of bromodomain-containing protein 4 (BRD4), could have great potential in the treatment of cervical cancer. However, its clinical application is limited by its short plasma half-life and limited antitumor efficacy. In… read more here.
Keywords: cddp jq1; cervical cancer; cddp; jq1 ... See more keywords