Small-molecule inhibition of the C. difficile FAS-II enzyme, FabK, results in selective activity.
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DOI: 10.1021/acschembio.9b00293
Abstract: Clostridioides difficile infection (CDI) is a leading cause of significant morbidity, mortality, and healthcare-related costs in the United States. After standard therapy, recurrence rates remain high and multiple recurrences are not uncommon. Causes include treatments… read more here.
Keywords: narrow spectrum; fabk; inhibition; small molecule ... See more keywords