Characterization of the first microRNA in human CDH1 that affects cell cycle and apoptosis and indicates breast cancers progression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30211
Abstract: The E‐cadherin protein (Cadherin 1, gene: CDH1), a master regulator of the human epithelial homeostasis, contributes to the epithelial‐mesenchymal transition (EMT) which confers cell migratory features to the cells. The EMT is central to many… read more here.
Keywords: cdh1; microrna human; first microrna; characterization first ... See more keywords
Frequency of CDH1 germline variants and contribution of dietary habits in early age onset gastric cancer patients in Brazil
Sign Up to like & getrecommendations! Published in 2019 at "Gastric Cancer"
DOI: 10.1007/s10120-019-00945-9
Abstract: IntroductionThe contribution of CDH1 germline variants to gastric cancer burden among young adults is unknown in Brazil. We aimed to evaluate the frequency of CDH1 germline variants and the diet/lifestyle habits in early age onset… read more here.
Keywords: gastric cancer; cdh1; cdh1 germline; germline variants ... See more keywords
APC/C CDH1 ubiquitinates IDH2 contributing to ROS increase in mitosis.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.110087
Abstract: NADPH is a cofactor used by reactive oxygen species (ROS) scavenging enzymes to block ROS produced in cells. Recently, it was shown that in cancer cells, ROS progressively increases in tune to cell cycle leading… read more here.
Keywords: cdh1; mitosis; ros increase; apc cdh1 ... See more keywords
Multidisciplinary management of CDH1 germinal mutation and prophylactic management hereditary lobular breast cancer: A case report
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2019.03.053
Abstract: Highlights • Currently, there is no indication to perform prophylactic mastectomy in CDH1 mutation carriers: breast surveillance is recommended.• To reduce the psychological impact due to bilateral prophylactic mastectomy, that is followed by immediate breast… read more here.
Keywords: cdh1; breast; case; management ... See more keywords
Upregulation of Cdh1 signaling in the hippocampus attenuates brain damage after transient global cerebral ischemia in rats
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2017.07.005
Abstract: &NA; Cerebral ischemia is a major cause of brain dysfunction. The E3 ubiquitin ligase anaphase‐promoting complex and its coactivator Cdh1 have been reported to be involved in the regulation of neuronal survival, differentiation, axonal growth… read more here.
Keywords: cdh1; cerebral ischemia; transient global; ischemia ... See more keywords
Cdh1-Mediated Metabolic Switch from Pentose Phosphate Pathway to Glycolysis Contributes to Sevoflurane-Induced Neuronal Apoptosis in Developing Brain.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.8b00644
Abstract: Cdh1 is a regulatory subunit of the anaphase promoting complex/cyclosome (APC/C), known to be involved in regulating neuronal survival. The role of Cdh1 in volatile anesthetics-induced neuronal apoptosis in the developing brain is unknown. In… read more here.
Keywords: cdh1; glycolysis; developing brain; pathway ... See more keywords
Variants in members of the cadherin–catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Human Genetics"
DOI: 10.1038/s41431-017-0010-5
Abstract: Blepharocheilodontic syndrome (BCDS) consists of lagophthalmia, ectropion of the lower eyelids, distichiasis, euryblepharon, cleft lip/palate and dental anomalies and has autosomal dominant inheritance with variable expression. We identified heterozygous variants in two genes of the… read more here.
Keywords: cdh1; blepharocheilodontic syndrome; ctnnd1; catenin ... See more keywords
SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1291479
Abstract: ABSTRACT SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, the mechanism by which SPHK1 signaling promotes… read more here.
Keywords: cdh1; degradation; sphk1; lysosomal degradation ... See more keywords
A Novel CDH1 Mutation Causing Reduced E-Cadherin Dimerization Is Associated with Nonsyndromic Cleft Lip With or Without Cleft Palate.
Sign Up to like & getrecommendations! Published in 2019 at "Genetic testing and molecular biomarkers"
DOI: 10.1089/gtmb.2019.0092
Abstract: Aims: Cleft lip with or without cleft palate (CL/P) is a common birth defect with the average prevalence of 1/700 to 1/1000. Almost 70% of CL/P patients belong to nonsyndromic CL/P (NSCL/P). The aim of… read more here.
Keywords: cdh1; lip without; dimerization; cleft ... See more keywords
Inactivation of TRP53, PTEN, RB1, and/or CDH1 in the ovarian surface epithelium induces ovarian cancer transformation and metastasis
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioaa008
Abstract: Abstract Ovarian cancer (OvCa) remains the most common cause of death from gynecological malignancies. Genetically engineered mouse models have been used to study initiation, origin, progression, and/or mechanisms of OvCa. Based on the clinical features… read more here.
Keywords: cdh1; pten rb1; trp53 pten; inactivation ... See more keywords
A novel human Cdh1 mutation impairs anaphase promoting complex/cyclosome activity resulting in microcephaly, psychomotor retardation, and epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14828
Abstract: The Fizzy‐related protein 1 (Fzr1) gene encodes Cdh1 protein, a coactivator of the E3 ubiquitin ligase anaphase‐promoting complex/cyclosome (APC/C). Previously, we found that genetic ablation of Fzr1 promotes the death of neural progenitor cells leading… read more here.
Keywords: epilepsy; cdh1; microcephaly psychomotor; psychomotor retardation ... See more keywords