The transcription factors Junb and Fosl2 cooperate to regulate Cdh3 expression in 15P‐1 Sertoli cells
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23656
Abstract: In Sertoli cells of the testis, cadherins (Cdh) are important cell‐to‐cell interaction proteins and contribute to the formation of the blood‐testis barrier being essential for germ cells' protection. P‐cadherin or Cdh3 is only expressed in… read more here.
Keywords: cdh3; junb fosl2; 15p sertoli; transcription factors ... See more keywords
A novel pathogenic CDH3 variant underlying heredity hypotrichosis simplex detected by whole-exome sequencing (WES)—a case report
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a006225
Abstract: Heredity hypotrichosis simplex (HHS) is a rare nonsyndromic disease form of hypotrichosis simplex (HS) characterized by progressive hair follicle (HF) miniaturization. It is usually inherited in an autosomal dominant manner. The differential diagnosis of HHS… read more here.
Keywords: hypotrichosis simplex; heredity; report; cdh3 ... See more keywords
Abstract 4823: CDH3-targeted ADC and CAR-T immunotherapies for metastatic double-negative prostate cancer and triple-negative breast cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4823
Abstract: Double-negative prostate cancer (DNPC) and triple-negative breast cancer (TNBC) are two challenging malignancies characterized by frequent metastasis and resistance to current therapies. Among them, DNPC may share similar traits with basal-like prostate cancer. These aggressive… read more here.
Keywords: cancer; breast cancer; prostate; car ... See more keywords
Synergistic potential of CDH3 in targeting CRC metastasis and enhancing immunotherapy
Sign Up to like & getrecommendations! Published in 2025 at "BMC Cancer"
DOI: 10.1186/s12885-025-13845-2
Abstract: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, particularly due to advanced-stage metastasis. P-cadherin (CDH3), a potential therapeutic target, is highly expressed in CRC tissues and associated with poor prognosis and metastasis. However,… read more here.
Keywords: role; crc metastasis; cdh3; potential cdh3 ... See more keywords
CDH3 Is an Effective Serum Biomarker of Colorectal Cancer Distant Metastasis Patients
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Cancer"
DOI: 10.7150/jca.98337
Abstract: Few robust biomarkers are available for distant metastatic colorectal cancer (CRC) patients. Aberrant high expression of CDH3 has been reported in advanced CRC patients, but the value of CDH3 as a biomarker for the diagnosis… read more here.
Keywords: crc patients; serum; serum cdh3; cdh3 ... See more keywords