Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.10.042
Abstract: Summary Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system.… read more here.
Keywords: cdk; system; cdc37; hsp90 system ... See more keywords
Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c02190
Abstract: Inhibition of cyclin-dependent kinases (CDKs) has become an effective therapeutic strategy for treating various diseases, especially cancer. Over almost three decades, although great efforts have been made to discover CDK inhibitors, many of which have… read more here.
Keywords: discovery; lessons learned; cdk; cyclin dependent ... See more keywords
Quantifying CDK inhibitor selectivity in live cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16559-0
Abstract: Concerted multidisciplinary efforts have led to the development of Cyclin-Dependent Kinase inhibitors (CDKi’s) as small molecule drugs and chemical probes of intracellular CDK function. However, conflicting data has been reported on the inhibitory potency of… read more here.
Keywords: cdk inhibitor; cdk inhibitors; quantifying cdk; cdk ... See more keywords
A quantitative and spatial analysis of cell cycle regulators during the fission yeast cycle
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2206172119
Abstract: We have carried out a systems-level analysis of the spatial and temporal dynamics of cell cycle regulators in the fission yeast Schizosaccharomyces pombe. In a comprehensive single cell analysis we have precisely quantified the levels… read more here.
Keywords: cell; cycle; cell cycle; cycle regulators ... See more keywords
Better together: Unifying discordant cell-cycle oscillator models
Sign Up to like & getrecommendations! Published in 2018 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1389197
Abstract: Biological oscillators have fascinated researchers for decades, and debates concerning the control systems that underlie them have often been fierce. One oscillator essential to all eukaryotes drives progression through the sequential events of the cell… read more here.
Keywords: cdk; cell cycle; transcriptional oscillations; cycle ... See more keywords
Polyclonal RB1 mutations and acquired resistance to CDK 4/6 inhibitors in patients with metastatic breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx784
Abstract: Background While deregulation of the cyclin D1-CDK4/6-retinoblastoma pathway is common in hormone receptor positive (HR+) breast cancer, Rb is usually intact in HR+ breast cancer, and targeted CDK 4/6 inhibitors that act upstream of Rb, are… read more here.
Keywords: cdk inhibitors; cdk; breast cancer; rb1 ... See more keywords
The fission yeast S-phase cyclin Cig2 can drive mitosis.
Sign Up to like & getrecommendations! Published in 2021 at "Genetics"
DOI: 10.1093/genetics/iyaa002
Abstract: Commitment to mitosis is regulated by cyclin-dependent kinase (CDK) activity. In the fission yeast Schizosaccharomyces pombe, the major B-type cyclin, Cdc13, is necessary and sufficient to drive mitotic entry. Furthermore, Cdc13 is also sufficient to… read more here.
Keywords: phase; mitosis; cdk; drive ... See more keywords
Factors associated with CDK 4/6 inhibitor use for patients with advanced, hormone positive, HER-2-negative breast cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2022.40.16_suppl.e13038
Abstract: e13038 Background: “CDK4/6 inhibitors have emerged as a standard of care for patients with HR-positive, HER2-negative advanced breast cancer.” Wayne Kuznar ASCO Reading Room 10.29.2019. Within an academic institution there were concerns that CDK 4/6… read more here.
Keywords: breast cancer; use; cdk; cdk inhibitors ... See more keywords
Role of p27Kip1 as a transcriptional regulator
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25447
Abstract: The protein p27Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase (Cdk) inhibitors. It interacts with both the catalytic and the regulatory subunit (cyclin) and introduces a region into the catalytic cleave of… read more here.
Keywords: transcriptional regulator; cdk; role p27kip1;
An Overview of CDK Enzyme Inhibitors in Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Current cancer drug targets"
DOI: 10.2174/1568009623666230320144713
Abstract: The ability to address the cell cycle in cancer therapy brings up new medication development possibilities. Cyclin-dependent kinases are a group of proteins that control the progression of the cell cycle. The CDK/cyclin complexes are… read more here.
Keywords: cdk inhibitors; pan cdk; cancer therapy; cancer ... See more keywords
Docking to a Basic Helix Promotes Specific Phosphorylation by G1-Cdk1
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22179514
Abstract: Cyclins are the activators of cyclin-dependent kinase (CDK) complex, but they also act as docking scaffolds for different short linear motifs (SLiMs) in CDK substrates and inhibitors. According to the unified model of CDK function,… read more here.
Keywords: cdk; docking basic; promotes specific; helix promotes ... See more keywords