The emerging roles of the CDK/cyclin complexes in antiviral innate immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medical virology"
DOI: 10.1002/jmv.27554
Abstract: More than 20 members of the human Cyclin-dependent kinases (CDKs) family share the feature of being activated by cyclins. CDKs have been involved in diverse biological processes, such as cell cycle, transcription, DNA damage response,… read more here.
Keywords: cdk cyclin; cyclin complexes; antiviral innate; innate immunity ... See more keywords
Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26175324
Abstract: Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary evaluated for their inhibitory activities over VEGFR-2, CDK-1/cyclin B and HER-2. Compound 15l showed the… read more here.
Keywords: compound 15l; cdk; cdk cyclin; vitro silico ... See more keywords