Use of cyclin-dependent kinase (CDK) 4/6 inhibitors for hormone receptor-positive, human epidermal growth factor receptor 2-negative, metastatic breast cancer: a roundtable discussion by The Breast Cancer Therapy Expert Group (BCTEG)
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DOI: 10.1007/s10549-018-4783-1
Abstract: PurposeTo provide an overview of clinical data supporting the use of cyclin-dependent kinases 4 and 6 (CDK 4/6) inhibitors in the treatment of hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2−), metastatic breast… read more here.
Keywords: therapy; cdk inhibitors; breast cancer; cancer ... See more keywords
Cyclin-dependent kinase (CDK) inhibitors in solid tumors: a review of clinical trials
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DOI: 10.1007/s12094-021-02688-5
Abstract: Cyclin-dependent kinases (CDKs) play a key regulating role in the cell cycle, which is almost universally altered in cancer, leading to sustained proliferation. Early pan-CDK inhibitors showed poor results in clinical trials for solid malignancies,… read more here.
Keywords: cdk inhibitors; solid tumors; cyclin dependent; inhibitors solid ... See more keywords
Lessons Learned from Past Cyclin-Dependent Kinase Drug Discovery Efforts.
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DOI: 10.1021/acs.jmedchem.1c02190
Abstract: Inhibition of cyclin-dependent kinases (CDKs) has become an effective therapeutic strategy for treating various diseases, especially cancer. Over almost three decades, although great efforts have been made to discover CDK inhibitors, many of which have… read more here.
Keywords: discovery; lessons learned; cdk; cyclin dependent ... See more keywords
Quantifying CDK inhibitor selectivity in live cells
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DOI: 10.1038/s41467-020-16559-0
Abstract: Concerted multidisciplinary efforts have led to the development of Cyclin-Dependent Kinase inhibitors (CDKi’s) as small molecule drugs and chemical probes of intracellular CDK function. However, conflicting data has been reported on the inhibitory potency of… read more here.
Keywords: cdk inhibitor; cdk inhibitors; quantifying cdk; cdk ... See more keywords
Cyclin-dependent kinase inhibitors for the treatment of lung cancer
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DOI: 10.1080/14656566.2020.1738385
Abstract: ABSTRACT Introduction Cyclin-dependent kinases (CDKs) are critical regulators of cell cycle progression in both normal and malignant cells, functioning through complex molecular interactions. Deregulation of CDK-dependent pathways is commonly found in both non-small cell and… read more here.
Keywords: cancer; cdk inhibitors; cyclin dependent; lung cancer ... See more keywords
Design, synthesis and biological evaluation of 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives as CDK inhibitors
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DOI: 10.1080/14756366.2023.2169282
Abstract: Abstract To explore the potential use of CDK inhibitors in pancreatic ductal adenocarcinoma (PDAC) therapy, a series of novel 2-((4-sulfamoylphenyl)amino)-pyrrolo[2,3-d]pyrimidine derivatives was designed, synthesised, and investigated for inhibition on both CDK kinase activity and cellular… read more here.
Keywords: sulfamoylphenyl amino; cdk inhibitors; pyrrolo pyrimidine; pyrimidine derivatives ... See more keywords
Polyclonal RB1 mutations and acquired resistance to CDK 4/6 inhibitors in patients with metastatic breast cancer
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DOI: 10.1093/annonc/mdx784
Abstract: Background While deregulation of the cyclin D1-CDK4/6-retinoblastoma pathway is common in hormone receptor positive (HR+) breast cancer, Rb is usually intact in HR+ breast cancer, and targeted CDK 4/6 inhibitors that act upstream of Rb, are… read more here.
Keywords: cdk inhibitors; cdk; breast cancer; rb1 ... See more keywords
P13.11 Transcriptional CDK inhibitors, CYC065 and THZ1 promote apoptosis in preclinical models of primary and recurrent GBM tumour cells and glioma stem cells
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DOI: 10.1093/neuonc/noab180.119
Abstract: Activation of cyclin-dependent kinases (CDKs) contributes to the uncontrolled proliferation of tumour cells. Genomic alterations that lead to the constitutive activation of CDKs are a feature of many tumours including glioblastoma (GBM), the most common… read more here.
Keywords: primary recurrent; cdk inhibitors; apoptosis; gbm ... See more keywords
Neoadjuvant Therapy of Cyclin-Dependent Kinase 4/6 Inhibitors Combined with Endocrine Therapy in HR+/HER2− Breast Cancer: A Systematic Review and Meta-Analysis
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DOI: 10.1159/000518573
Abstract: Background: Cyclin-dependent kinase (CDK) 4/6 inhibitors have been advocated for adjuvant therapy of metastatic hormone receptor (HR)+/human epidermal growth factor receptor 2 (HER2)− breast cancer (BC). However, the efficiency of adding CDK 4/6 inhibitors to… read more here.
Keywords: cdk inhibitors; cyclin dependent; cancer; therapy ... See more keywords
Haematopoietic cytopenia associated with cyclin-dependent kinase 4/6 inhibitors: A real-world study of data from the food and drug administration adverse event reporting system database
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DOI: 10.1177/03946320221145520
Abstract: Objective The haematopoietic cytopenia (HC) of the cyclin-dependent kinase (CDK)4/6 inhibitors was evaluated using the Food and Drug Administration Adverse Event Reporting System (FAERS). Method Data from 1 January 2015 to 31 December 2021 has… read more here.
Keywords: cdk inhibitors; food drug; dependent kinase; cyclin dependent ... See more keywords
Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
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DOI: 10.1186/s13027-020-00295-7
Abstract: The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor… read more here.
Keywords: kinases cdk; cdk inhibitors; dependent kinases; cyclin dependent ... See more keywords