Inhibition of CDK-mediated Smad3 phosphorylation reduces the Pin1-Smad3 interaction and aggressiveness of triple negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1338988
Abstract: ABSTRACT Triple negative breast cancer (TNBC) is a highly aggressive breast cancer subtype that lacks effective targeted therapies. Although TNBC is not defined by specific therapeutic targets, a subset of patients have tumors that overexpress… read more here.
Keywords: cdk mediated; breast; interaction; smad3 phosphorylation ... See more keywords
Leukemogenic Functions of Mutant ASXL1 Are Regulated By CDK-Mediated Phosphorylation
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DOI: 10.1182/blood-2019-125959
Abstract: Additional sex combs-like 1 (ASXL1) is recurrently mutated in various myeloid neoplasms and its mutations confer poor prognosis. Most of the ASXL1 mutations in myeloid malignancies are frameshift or nonsense mutations, leading to expression of… read more here.
Keywords: asxl1; cdk mediated; leukemogenic functions; phosphorylation ... See more keywords