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   Articles with "cdk1" as a keyword



Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions

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recommendations! Published in 2023 at "Advanced Science"

DOI: 10.1002/advs.202205873

Abstract: Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo‐resistance, metastasis, and TNBC‐related death.… read more here.

Keywords: resistance metastasis; phosphorylation usp29; twist1; cdk1 ... See more keywords
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CDK1 promotes the stemness of lung cancer cells through interacting with Sox2

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recommendations! Published in 2021 at "Clinical and Translational Oncology"

DOI: 10.1007/s12094-021-02575-z

Abstract: The promoting roles of cyclin dependent kinase 1 (CDK1) have been revealed in various tumors, however, its effects in the progression of cancer stem cells are still confusing. This work aims to explore the roles… read more here.

Keywords: cdk1; stemness lung; lung cancer; cancer cells ... See more keywords
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Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma.

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recommendations! Published in 2021 at "Biochemical pharmacology"

DOI: 10.1016/j.bcp.2021.114806

Abstract: The pathological changes and possible underlying molecular mechanisms of hepatocellular carcinoma (HCC) are currently unclear. Effective treatment of this pathological state remains a challenge. The purpose of this study is to obtain some key genes… read more here.

Keywords: hepatocellular carcinoma; cdk1; target lycorine; cyclin dependent ... See more keywords

Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance.

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recommendations! Published in 2019 at "Cancer letters"

DOI: 10.1016/j.canlet.2018.11.019

Abstract: A mammalian cell houses two genomes located separately in the nucleus and mitochondria. During evolution, communications and adaptations between these two genomes occur extensively to achieve and sustain homeostasis for cellular functions and regeneration. Mitochondria… read more here.

Keywords: cdk1; mitochondrial bioenergetics; cyclin cdk1; cell cycle ... See more keywords

Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells

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recommendations! Published in 2018 at "Current Biology"

DOI: 10.1016/j.cub.2018.09.059

Abstract: Summary Distinct protein phosphorylation levels in interphase and M phase require tight regulation of Cdk1 activity [1, 2]. A bistable switch, based on positive feedback in the Cdk1 activation loop, has been proposed to generate… read more here.

Keywords: cdk1; pp2a b55; feedback; biology ... See more keywords
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Life in the (Pluripotent) Fast Lane: Cdk1 Preserves the Epigenome to Maintain Pluripotency.

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recommendations! Published in 2020 at "Molecular cell"

DOI: 10.1016/j.molcel.2020.04.025

Abstract: Michowski and colleagues (2020) engineered analog-sensitive Cdk1 knockin mice to identify Cdk1 targets in embryonic stem cells, which led them to discover a novel function for Cdk1 in shaping the epigenetic landscape by direct regulation… read more here.

Keywords: cdk1; cdk1 preserves; lane cdk1; fast lane ... See more keywords

CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency

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recommendations! Published in 2017 at "Cell Death and Differentiation"

DOI: 10.1038/cdd.2016.84

Abstract: The mechanisms of how signaling pathways are coordinated and integrated for the maintenance of the self-renewal of human embryonic stem cells (hESCs) and the acquisition of pluripotency in reprogramming are still only partly understood. CDK1… read more here.

Keywords: cdk1; cdk1 pdk1; pi3k akt; pluripotency ... See more keywords

Comprehensive multi-omics analysis reveals WEE1 as a synergistic lethal target with hyperthermia through CDK1 super-activation

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-46358-w

Abstract: Hyperthermic intraperitoneal chemotherapy’s role in ovarian cancer remains controversial, hindered by limited understanding of hyperthermia-induced tumor cellular changes. This limits developing potent combinatory strategies anchored in hyperthermic intraperitoneal therapy (HIPET). Here, we perform a comprehensive… read more here.

Keywords: cdk1; cancer; multi omics; hyperthermia ... See more keywords

CDK1-mediated phosphorylation of LDHA fuels mitosis through LDHB-dependent lactate oxidation

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recommendations! Published in 2025 at "EMBO Reports"

DOI: 10.1038/s44319-025-00573-8

Abstract: While cancer cells overexpress lactate dehydrogenase A (LDHA) to support glycolytic flux and lactate production, the role of LDHB—which preferentially catalyzes lactate oxidation—remains unclear. Here, we demonstrate that LDHB, but not LDHA, is essential for… read more here.

Keywords: cdk1; chromosome segregation; lactate oxidation; phosphorylation ... See more keywords

Paclitaxel inhibits proliferation by negatively regulating Cdk1-cell cycle axis in rat airway smooth muscle cells

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recommendations! Published in 2024 at "Journal of Asthma"

DOI: 10.1080/02770903.2024.2349599

Abstract: Abstract Objective Paclitaxel exhibits outstanding biological activities in inhibiting cell proliferation and inducing cell apoptosis. However, the effects of paclitaxel on airway smooth muscle cells (ASMCs) have not been reported yet. The purpose of this… read more here.

Keywords: cdk1; cell cycle; paclitaxel inhibits; cell ... See more keywords

Not all roads lead to Cdk1

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recommendations! Published in 2017 at "Cell Cycle"

DOI: 10.1080/15384101.2016.1274585

Abstract: In response to DNA damage or replication stress, DNA damage and replication checkpoints are activated and play critical roles in preventing entry into mitosis. The checkpoint-mediated G2 delay is orchestrated by the apical kinases ATR… read more here.

Keywords: dna damage; cdk1; mitosis; condensation ... See more keywords