Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205873
Abstract: Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo‐resistance, metastasis, and TNBC‐related death.… read more here.
Keywords: resistance metastasis; phosphorylation usp29; twist1; cdk1 ... See more keywords
CDK1 promotes the stemness of lung cancer cells through interacting with Sox2
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Translational Oncology"
DOI: 10.1007/s12094-021-02575-z
Abstract: The promoting roles of cyclin dependent kinase 1 (CDK1) have been revealed in various tumors, however, its effects in the progression of cancer stem cells are still confusing. This work aims to explore the roles… read more here.
Keywords: cdk1; stemness lung; lung cancer; cancer cells ... See more keywords
Cyclin-dependent kinase 1 as a potential target for lycorine against hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114806
Abstract: The pathological changes and possible underlying molecular mechanisms of hepatocellular carcinoma (HCC) are currently unclear. Effective treatment of this pathological state remains a challenge. The purpose of this study is to obtain some key genes… read more here.
Keywords: hepatocellular carcinoma; cdk1; target lycorine; cyclin dependent ... See more keywords
Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.11.019
Abstract: A mammalian cell houses two genomes located separately in the nucleus and mitochondria. During evolution, communications and adaptations between these two genomes occur extensively to achieve and sustain homeostasis for cellular functions and regeneration. Mitochondria… read more here.
Keywords: cdk1; mitochondrial bioenergetics; cyclin cdk1; cell cycle ... See more keywords
Two Interlinked Bistable Switches Govern Mitotic Control in Mammalian Cells
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.09.059
Abstract: Summary Distinct protein phosphorylation levels in interphase and M phase require tight regulation of Cdk1 activity [1, 2]. A bistable switch, based on positive feedback in the Cdk1 activation loop, has been proposed to generate… read more here.
Keywords: cdk1; pp2a b55; feedback; biology ... See more keywords
Life in the (Pluripotent) Fast Lane: Cdk1 Preserves the Epigenome to Maintain Pluripotency.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.04.025
Abstract: Michowski and colleagues (2020) engineered analog-sensitive Cdk1 knockin mice to identify Cdk1 targets in embryonic stem cells, which led them to discover a novel function for Cdk1 in shaping the epigenetic landscape by direct regulation… read more here.
Keywords: cdk1; cdk1 preserves; lane cdk1; fast lane ... See more keywords
CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2016.84
Abstract: The mechanisms of how signaling pathways are coordinated and integrated for the maintenance of the self-renewal of human embryonic stem cells (hESCs) and the acquisition of pluripotency in reprogramming are still only partly understood. CDK1… read more here.
Keywords: cdk1; cdk1 pdk1; pi3k akt; pluripotency ... See more keywords
Not all roads lead to Cdk1
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2016.1274585
Abstract: In response to DNA damage or replication stress, DNA damage and replication checkpoints are activated and play critical roles in preventing entry into mitosis. The checkpoint-mediated G2 delay is orchestrated by the apical kinases ATR… read more here.
Keywords: dna damage; cdk1; mitosis; condensation ... See more keywords
Wee1 and Cdc25: Tools, pathways, mechanisms, questions
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1302229
Abstract: How are physiological signals integrated into a biochemical switch governing cell division? Cells enter mitosis and divide due to regulated activation of the cyclin-dependent kinase Cdk1. During interphase, Cdk1 is inactive due to inhibitory phosphorylation… read more here.
Keywords: cdk1; cdc25; wee1 cdc25; cell ... See more keywords
Cyclin dependent kinase 1 (CDK1) positively regulates cardiac hypertrophy and fibrosis via TGF-beta pathway
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3743
Abstract: Transforming growth factor beta (TGF-β) critically mediates cardiac fibrosis by transforming fibroblasts to myofibroblasts in pathological conditions. Cyclin dependent kinases (CDKs), cell cycle-regulating proteins, are known to be intimately involved in cardiac fibrosis. Among CDK… read more here.
Keywords: cdk1; fibrosis; cardiac fibrosis; tgf ... See more keywords
NCAPD2 promotes breast cancer progression through E2F1 transcriptional regulation of CDK1
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15347
Abstract: Breast cancer (BC) is a serious threat to women’s health worldwide. Non‐SMC condensin I complex subunit D2 (NCAPD2) is a regulatory subunit of the coagulin I complex, which is mainly involved in chromosome coagulation and… read more here.
Keywords: cdk1; breast cancer; progression; ncapd2 promotes ... See more keywords