Abstract 1118: Synthetic lethality of CDK12 inhibition in tumors with EWS/FLI rearrangements
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DOI: 10.1158/1538-7445.am2017-1118
Abstract: THZ1 is a potent, covalent inhibitor of the transcriptional CDKs, CDK7/12/13. Chemical genomic profiling of THZ1 across >1,000 diverse cancer cell lines revealed that EWS/FLI- rearranged Ewing sarcoma cells were remarkably sensitive to this molecule.… read more here.
Keywords: cdk12 inhibition; ewing sarcoma; cdk12; ews fli ... See more keywords