Dual inhibition of CDK12/CDK13 targets both tumor and immune cells in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0222
Abstract: Therapeutic perturbation of cyclin-dependent kinase 12 (CDK12) is proposed to have pleiotropic effects in ovarian cancer, including direct cytotoxicity against tumor cells and indirect induction of immunogenicity that confer synthetic sensitivity to immune-based treatment. However,… read more here.
Keywords: cdk13; cdk12 cdk13; ovarian cancer; tumor immune ... See more keywords
ARID1A loss promotes RNA editing of CDK13 in an ADAR1-dependent manner
Sign Up to like & getrecommendations! Published in 2024 at "BMC Biology"
DOI: 10.1186/s12915-024-01927-9
Abstract: ARID1A, a subunit of the SWI/SNF chromatin remodeling complex, is thought to play a significant role both in tumor suppression and tumor initiation, which is highly dependent upon context. Previous studies have suggested that ARID1A… read more here.
Keywords: arid1a loss; rna editing; cdk13; promotes rna ... See more keywords
Mouse Model of Congenital Heart Defects, Dysmorphic Facial Features and Intellectual Developmental Disorders as a Result of Non-functional CDK13
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00155
Abstract: Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene. In order to assess the loss of function of Cdk13 during mouse development,… read more here.
Keywords: cdk13; defects dysmorphic; heart; dysmorphic facial ... See more keywords