CDK19 regulates the proliferation of hematopoietic stem cells and acute myeloid leukemia cells by suppressing p53-mediated transcription of p21
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DOI: 10.1038/s41375-022-01512-5
Abstract: The cell cycle progression of hematopoietic stem cells (HSCs) and acute myeloid leukemia (AML) cells is precisely controlled by multiple regulatory factors. However, the underlying mechanisms are not fully understood. Here, we find that cyclin-dependent… read more here.
Keywords: p53; proliferation; cdk19; stem cells ... See more keywords
Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer
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DOI: 10.1038/s41388-018-0316-y
Abstract: CDK8 is a transcription-regulating kinase that controls TGF-β/BMP-responsive SMAD transcriptional activation and turnover through YAP1 recruitment. However, how the CDK8/YAP1 pathway influences SMAD1 response in cancer remains unclear. Here we report that SMAD1-driven epithelial-to-mesenchymal transition… read more here.
Keywords: mediator kinase; cdk19; cdk8; cancer ... See more keywords
Hsa_circ_0006692 Promotes Lung Cancer Progression via miR-205-5p/CDK19 Axis
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DOI: 10.3390/genes13050846
Abstract: Circular RNA (CircRNA) is related to tumor development. Nevertheless, the regulation and function of hsa_circ_0006692 and its interactions with miR-205-5p and CDK19 in the development of non-small-cell lung cancer (NSCLC) were un-explored. The correlations of… read more here.
Keywords: lung cancer; mir 205; hsa circ; cdk19 ... See more keywords