Protein Dynamics Enables Phosphorylation of Buried Residues in Cdk2/Cyclin-A-Bound p27.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.06.040
Abstract: Proteins carry out a wide range of functions that are tightly regulated in space and time. Protein phosphorylation is the most common post-translation modification of proteins and plays a key role in the regulation of… read more here.
Keywords: protein dynamics; phosphorylation buried; buried residues; phosphorylation ... See more keywords
Tetrahydroindazole inhibitors of CDK2/cyclin complexes.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113232
Abstract: Over 50 tetrahydroindazoles were synthesized after 7-bromo-3,6,6-trimethyl-1-(pyridin-2-yl)-5,6,7,7a-tetrahydro-1H-indazol-4(3aH)-one (3) was identified as a hit compound in a high throughput screen for inhibition of CDK2 in complex with cyclin A. The activity of the most promising analogues… read more here.
Keywords: inhibitors cdk2; tetrahydroindazole inhibitors; cyclin; cdk2 cyclin ... See more keywords
Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition
Sign Up to like & getrecommendations! Published in 2021 at "Cell Cycle"
DOI: 10.1080/15384101.2021.1938813
Abstract: ABSTRACT Cyclin-dependent kinase (CDK) 1 complexed with cyclin B is a driver of mitosis, while CDK2 drives S phase entry and replicon initiation. CDK2 activity increases as cells progress through S phase, and its cyclin… read more here.
Keywords: inhibition; cyclin; activation; cdc25a ... See more keywords