Ablation of cdk4 and cdk6 affects proliferation of basal progenitor cells in the developing dorsal and ventral forebrain
Sign Up to like & getrecommendations! Published in 2018 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22588
Abstract: Little is known about the molecular players driving proliferation of neural progenitor cells (NPCs) during embryonic mouse development. Here, we demonstrate that proliferation of NPCs in the developing forebrain depends on a particular combination of… read more here.
Keywords: cdk4 cdk6; progenitor cells; proliferation; progenitor ... See more keywords
Abstract PS19-10: Preclinical head-to-head comparison of CDK4/6 inhibitor activity toward CDK4 vs CDK6
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs20-ps19-10
Abstract: Background: The cyclin-dependent kinase (CDK) 4/6 inhibitors ribociclib, abemaciclib, and palbociclib have been established as effective treatment options for hormone receptor–positive (HR+) human epidermal growth factor receptor 2–negative (HER2–) breast cancer. While these agents have… read more here.
Keywords: cdk4 cdk6; cdk4 inhibitor; cancer; head ... See more keywords
CDK4/CDK6 Inhibitors Synergize with Midostaurin, Avapritinib, and Nintedanib in Inducing Growth Inhibition in KIT D816V+ Neoplastic Mast Cells
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14133070
Abstract: Simple Summary Advanced systemic mastocytosis (AdvSM) is a rare malignant disease with a poor prognosis due to the drug resistance of neoplastic mast cells. We found that drugs targeting the cell cycle regulators CDK4 and… read more here.
Keywords: growth; cdk6 inhibitors; mast cells; cdk4 cdk6 ... See more keywords