Simvastatin induces G1 arrest by up‐regulating GSK3β and down‐regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26156
Abstract: Simvastatin (SIM), a widely used cholesterol‐lowering drug, also exhibits tumor‐suppressive potentials in several types of malignancy. Colorectal cancer (CRC), the third most common malignant neoplasm, accounts for the second most leading cause of cancer‐related deaths… read more here.
Keywords: cdk4 cyclin; colorectal cancer; cyclin; cancer cells ... See more keywords
Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1593708
Abstract: ABSTRACT Senescence is a tumor suppressor program characterized by a stable growth arrest while maintaining cell viability. Senescence-associated ribogenesis defects (SARD) have been shown to regulate senescence through the ability of the ribosomal protein S14… read more here.
Keywords: ribosomal protein; cdk4 cyclin; cell cycle; rpl22 el22 ... See more keywords
New pyridopyrimidine derivatives as dual EGFR and CDK4/cyclin D1 inhibitors: synthesis, biological screening and molecular modeling.
Sign Up to like & getrecommendations! Published in 2024 at "Future medicinal chemistry"
DOI: 10.1080/17568919.2024.2366147
Abstract: Aim: A series of pyridopyrimidine derivatives 5-20 was designed, synthesized and examined for antitumor activity using four types of malignant cells. Materials & methods: Cervical cancer (HeLa), hepatic cancer (HepG-2), breast cancer (MCF-7) and colon… read more here.
Keywords: egfr; cancer; cdk4 cyclin; cyclin ... See more keywords
Abstract 872: Deciphering the activation mechanism of CDK4/cyclin-D complex that differs from the CDK2/cyclin-E complex
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-872
Abstract: Cyclin-dependent protein kinases (CDKs) regulate the eukaryotic cell cycle progression. Dysregulated cell cycle leading to unscheduled cell proliferation is a characteristic of many cancer subtypes. Since some tumor cells require specific interphase CDKs for proliferation,… read more here.
Keywords: cancer; cdk4 cyclin; activation mechanism; cyclin complex ... See more keywords