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Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26156
Abstract: Simvastatin (SIM), a widely used cholesterol‐lowering drug, also exhibits tumor‐suppressive potentials in several types of malignancy. Colorectal cancer (CRC), the third most common malignant neoplasm, accounts for the second most leading cause of cancer‐related deaths…
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Keywords:
cdk4 cyclin;
colorectal cancer;
cyclin;
cancer cells ... See more keywords
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Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1593708
Abstract: ABSTRACT Senescence is a tumor suppressor program characterized by a stable growth arrest while maintaining cell viability. Senescence-associated ribogenesis defects (SARD) have been shown to regulate senescence through the ability of the ribosomal protein S14…
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Keywords:
ribosomal protein;
cdk4 cyclin;
cell cycle;
rpl22 el22 ... See more keywords
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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-872
Abstract: Cyclin-dependent protein kinases (CDKs) regulate the eukaryotic cell cycle progression. Dysregulated cell cycle leading to unscheduled cell proliferation is a characteristic of many cancer subtypes. Since some tumor cells require specific interphase CDKs for proliferation,…
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Keywords:
cancer;
cdk4 cyclin;
activation mechanism;
cyclin complex ... See more keywords