Articles with "cdk4 cyclin" as a keyword



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Simvastatin induces G1 arrest by up‐regulating GSK3β and down‐regulating CDK4/cyclin D1 and CDK2/cyclin E1 in human primary colorectal cancer cells

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Published in 2018 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.26156

Abstract: Simvastatin (SIM), a widely used cholesterol‐lowering drug, also exhibits tumor‐suppressive potentials in several types of malignancy. Colorectal cancer (CRC), the third most common malignant neoplasm, accounts for the second most leading cause of cancer‐related deaths… read more here.

Keywords: cdk4 cyclin; colorectal cancer; cyclin; cancer cells ... See more keywords
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Ribosomal protein RPL22/eL22 regulates the cell cycle by acting as an inhibitor of the CDK4-cyclin D complex

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Published in 2019 at "Cell Cycle"

DOI: 10.1080/15384101.2019.1593708

Abstract: ABSTRACT Senescence is a tumor suppressor program characterized by a stable growth arrest while maintaining cell viability. Senescence-associated ribogenesis defects (SARD) have been shown to regulate senescence through the ability of the ribosomal protein S14… read more here.

Keywords: ribosomal protein; cdk4 cyclin; cell cycle; rpl22 el22 ... See more keywords
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Abstract 872: Deciphering the activation mechanism of CDK4/cyclin-D complex that differs from the CDK2/cyclin-E complex

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Published in 2023 at "Cancer Research"

DOI: 10.1158/1538-7445.am2023-872

Abstract: Cyclin-dependent protein kinases (CDKs) regulate the eukaryotic cell cycle progression. Dysregulated cell cycle leading to unscheduled cell proliferation is a characteristic of many cancer subtypes. Since some tumor cells require specific interphase CDKs for proliferation,… read more here.

Keywords: cancer; cdk4 cyclin; activation mechanism; cyclin complex ... See more keywords