Combination of cyclin-dependent kinase and immune checkpoint inhibitors for the treatment of bladder cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02609-5
Abstract: Perturbation of the CDK4/6 pathway is frequently observed in advanced bladder cancer. We investigated the potential of targeting this pathway alone or in combination with chemotherapy or immunotherapy as a therapeutic approach for the treatment… read more here.
Keywords: bladder cancer; palbociclib; treatment; cancer ... See more keywords
Sertad1 Induces Neurological Injury after Ischemic Stroke via the CDK4/p-Rb Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Molecules and Cells"
DOI: 10.14348/molcells.2021.0071
Abstract: SERTA domain-containing protein 1 (Sertad1) is upregulated in the models of DNA damage and Alzheimer’s disease, contributing to neuronal death. However, the role and mechanism of Sertad1 in ischemic/hypoxic neurological injury remain unclear. In the… read more here.
Keywords: cell; neurological injury; cdk4 pathway; ht22 cells ... See more keywords
Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma Cells via Inhibiting CDK4-RB Pathway
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01152
Abstract: Wogonin, an active component derived from Scutellaria baicalensis, has shown anti-tumor activities in several malignancies. However, the roles of wogonin in RCC cells remain elusive. Here, we explored the effects of wogonin on RCC cells… read more here.
Keywords: wogonin; inhibiting cdk4; resistance; rcc cells ... See more keywords