Cdk5 inhibition in the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis suppresses neurodegeneration and extends survival
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.16160
Abstract: Deregulated cyclin‐dependent kinase 5 (Cdk5) activity closely correlates with hyperphosphorylated tau, a common pathology found in neurodegenerative diseases. Previous postmortem studies had revealed increased Cdk5 immunoreactivity in amyotrophic lateral sclerosis (ALS); hence, we investigated the… read more here.
Keywords: mice; cdk5 inhibition; pathology; cdk5 ... See more keywords