mPTP opening caused by Cdk5 loss is due to increased mitochondrial Ca2+ uptake
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DOI: 10.1038/s41388-020-1188-5
Abstract: We previously demonstrated that loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death by inducing mitochondrial permeability transition pore (mPTP) opening (Oncogene 37, 1788–1804). However, the molecular mechanism by which Cdk5 loss causes… read more here.
Keywords: cdk5 loss; mitochondrial ca2; mptp opening; loss ... See more keywords