Identification of Novel Compounds Inhibiting the Kinase Activity of the CDK5/p25 Complex via Direct Binding to p25.
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DOI: 10.1021/acs.biochem.2c00691
Abstract: Tamoxifen, the gold standard drug for endocrine therapy for breast cancer, modulates the phosphorylation status of the TAU protein in Alzheimer's disease by inhibiting CDK5 kinase activity. Its binding to p25 prevents CDK5/p25 complexation and… read more here.
Keywords: kinase activity; p25 complex; p25; cdk5 p25 ... See more keywords