CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13438
Abstract: Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by distinctive structural features, but their partner CDKs remain elusive.… read more here.
Keywords: cell; cdk6; cancer cell; cyclin ... See more keywords
nc‐RNA‐mediated high expression of CDK6 correlates with poor prognosis and immune infiltration in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5260
Abstract: Emerging evidence manifests that cyclin‐dependent kinase 6 (CDK6) plays an essential part in the initiation and progression of several types of human cancer, and its descending expression is correlated with an adverse prognosis. However, the… read more here.
Keywords: prognosis; pancreatic cancer; rna mediated; expression ... See more keywords
SUZ12 promotes the malignant behavior of gastric cancer cells by CDKs.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23365
Abstract: Zeste 12 Homolog (SUZ12), as a transcription factor, has been found to be highly expressed in a variety of tumors and promote tumor progression. We focus on revealing its role and mechanism in gastric cancer.… read more here.
Keywords: malignant behavior; overexpression; suz12; cdk6 ... See more keywords
Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2135511
Abstract: Abstract Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design towards the CDK family. Multiple short molecular dynamics (MD) simulations combined with MM-GBSA approach are adopted to investigate… read more here.
Keywords: cdk2 cdk6; inhibitors towards; cdk6; towards cdk2 ... See more keywords
Circular RNA CDK6 suppresses cervical cancer proliferation and metastasis by sponging miR-449a
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2036898
Abstract: ABSTRACT Cervical cancer is a malignant tumor that severely threatens female health. Recently, more and more studies indicated that circRNA could function as a tumor activator or suppressor in cervical cell development. Therefore, we aimed… read more here.
Keywords: cervical cancer; mir 449a; proliferation metastasis; circcdk6 ... See more keywords
CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-17-0912
Abstract: Tumor formation is a multistep process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6 contributes to tumor formation by regulating transcriptional responses in a… read more here.
Keywords: cdk6 kinase; antagonizes p53; p53 induced; cdk6 antagonizes ... See more keywords
INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-1726
Abstract: Cyclin-dependent kinases 4 and 6 (CDK4/6), represent a major therapeutic vulnerability for breast cancer. The kinases are clinically targeted via ATP competitive inhibitors (CDK4/6i); however, drug resistance commonly emerges over time. To understand CDK4/6i resistance,… read more here.
Keywords: ink4 tumor; kinase; cdk6; resistance ... See more keywords
Effect of pH on the structure and function of cyclin-dependent kinase 6
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263693
Abstract: Cyclin-dependent kinase 6 (CDK6) is an important protein kinase that regulates cell growth, development, cell metabolism, inflammation, and apoptosis. Its overexpression is associated with reprogramming glucose metabolism through alternative pathways and apoptosis, which ultimately plays… read more here.
Keywords: cdk6; spectroscopy; structure; dependent kinase ... See more keywords
AC002454.1 and CDK6 synergistically promote Endometrial Cell Migration and Invasion in Endometriosis.
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DOI: 10.1530/rep-19-0005
Abstract: Previous lncRNA microarray screening found that the AC002454.1 gene was highly expressed in Endometriosis (EMS) and these expression levels were highly correlated with cyclin-dependent kinase-6 (CDK6). This study investigated the expression level and correlation between… read more here.
Keywords: cdk6; migration invasion; endometriosis; ac002454 cdk6 ... See more keywords
Expression and Significance of Cyclin-Dependent Protein Kinase 6 in Diffuse Large B-Cell Lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s380496
Abstract: Objective To study the relationship between cyclin-dependent protein kinase 6 (CDK6) expression in diffuse large B-cell lymphoma (DLBCL) and the clinical biological behavior and prognosis. Methods Data mining was performed using the Oncomine and The… read more here.
Keywords: dlbcl; cyclin dependent; expression; analysis ... See more keywords
LncRNA AWPPH accelerates the progression of non-small cell lung cancer by sponging miRNA-204 to upregulate CDK6.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202004_21008
Abstract: OBJECTIVE This study aims to uncover the function of long non-coding RNA (lncRNA) AWPPH in the progression of non-small cell lung cancer (NSCLC) and the potential mechanism. PATIENTS AND METHODS AWPPH and microRNA (miRNA-204) levels… read more here.
Keywords: a549 cells; cell; cdk6; lncrna awpph ... See more keywords