CDK6 is activated by the atypical cyclin I to promote E2F-mediated gene expression and cancer cell proliferation.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13438
Abstract: Cyclin-dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by distinctive structural features, but their partner CDKs remain elusive.… read more here.
Keywords: cell; cdk6; cancer cell; cyclin ... See more keywords
nc‐RNA‐mediated high expression of CDK6 correlates with poor prognosis and immune infiltration in pancreatic cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5260
Abstract: Emerging evidence manifests that cyclin‐dependent kinase 6 (CDK6) plays an essential part in the initiation and progression of several types of human cancer, and its descending expression is correlated with an adverse prognosis. However, the… read more here.
Keywords: prognosis; pancreatic cancer; rna mediated; expression ... See more keywords
SUZ12 promotes the malignant behavior of gastric cancer cells by CDKs.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of biochemical and molecular toxicology"
DOI: 10.1002/jbt.23365
Abstract: Zeste 12 Homolog (SUZ12), as a transcription factor, has been found to be highly expressed in a variety of tumors and promote tumor progression. We focus on revealing its role and mechanism in gastric cancer.… read more here.
Keywords: malignant behavior; overexpression; suz12; cdk6 ... See more keywords
ELF4/TRIB3/CDK6 Axis Promotes Cancer Stem Cell Activity in Endometrial Cancer
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.70113
Abstract: Endometrial cancer (EC) is the most prevalent gynecological malignancy globally. Here, we explored the role of E74‐like ETS transcription factor 4 (ELF4) in EC progression. Using the TISIDB web tool to analyze TCGA data, we… read more here.
Keywords: cancer; trib3 cdk6; elf4 trib3; cdk6 ... See more keywords
Binding selectivity-dependent molecular mechanism of inhibitors towards CDK2 and CDK6 investigated by multiple short molecular dynamics and free energy landscapes
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2135511
Abstract: Abstract Understanding selectivity-dependent molecular mechanism of inhibitors towards CDK2 over CDK6 is prominent for improving drug design towards the CDK family. Multiple short molecular dynamics (MD) simulations combined with MM-GBSA approach are adopted to investigate… read more here.
Keywords: cdk2 cdk6; inhibitors towards; cdk6; towards cdk2 ... See more keywords
Circular RNA CDK6 suppresses cervical cancer proliferation and metastasis by sponging miR-449a
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2036898
Abstract: ABSTRACT Cervical cancer is a malignant tumor that severely threatens female health. Recently, more and more studies indicated that circRNA could function as a tumor activator or suppressor in cervical cell development. Therefore, we aimed… read more here.
Keywords: cervical cancer; mir 449a; proliferation metastasis; circcdk6 ... See more keywords
Abstract PS12-07: Phase II clinical trial of palbociclib and binimetinib in advanced triple-negative breast cancer (TNBC) with hyperactivation of ERK and/or CDK4/6
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs23-ps12-07
Abstract: Background: We previously demonstrated that a kinase-based taxonomy of TNBC was most parsimonious than next-generation sequencing in defining TNBC subtypes associated with prognostic categories in early disease. The most aggressive TNBC variants were driven by… read more here.
Keywords: binimetinib; cancer; trial; cdk6 ... See more keywords
CDK6 Antagonizes p53-Induced Responses during Tumorigenesis.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-17-0912
Abstract: Tumor formation is a multistep process during which cells acquire genetic and epigenetic changes until they reach a fully transformed state. We show that CDK6 contributes to tumor formation by regulating transcriptional responses in a… read more here.
Keywords: cdk6 kinase; antagonizes p53; p53 induced; cdk6 antagonizes ... See more keywords
INK4 tumor suppressor proteins mediate resistance to CDK4/6 kinase inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-1726
Abstract: Cyclin-dependent kinases 4 and 6 (CDK4/6), represent a major therapeutic vulnerability for breast cancer. The kinases are clinically targeted via ATP competitive inhibitors (CDK4/6i); however, drug resistance commonly emerges over time. To understand CDK4/6i resistance,… read more here.
Keywords: ink4 tumor; kinase; cdk6; resistance ... See more keywords
Abstract Th0062: LMOD1 Inhibition Enhances Vascular Remodeling Through CDK6-mediated Smooth Muscle Cell Proliferation
Sign Up to like & getrecommendations! Published in 2025 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atv.45.suppl_1.th0062
Abstract: Background: Smooth muscle cells (SMCs) play a critical role in maintaining vascular integrity and regulating blood flow. Unlike many other cell types, SMCs can undergo phenotypic modulation in response to vascular injury and cardiovascular disease… read more here.
Keywords: cell; smc proliferation; smooth muscle; cdk6 ... See more keywords
Effect of pH on the structure and function of cyclin-dependent kinase 6
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0263693
Abstract: Cyclin-dependent kinase 6 (CDK6) is an important protein kinase that regulates cell growth, development, cell metabolism, inflammation, and apoptosis. Its overexpression is associated with reprogramming glucose metabolism through alternative pathways and apoptosis, which ultimately plays… read more here.
Keywords: cdk6; spectroscopy; structure; dependent kinase ... See more keywords