Cyclin‐dependent kinase 7 is essential for spermatogenesis by regulating retinoic acid signaling pathways and the STAT3 molecular pathway
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DOI: 10.1002/iub.2574
Abstract: Spermatogenesis is a complex process that requires precise regulation. Phosphorylation plays a role in spermatogenesis by regulating protein structure and activity. This study focused on cyclin‐dependent kinase 7 (CDK7), and explored its function and molecular… read more here.
Keywords: spermatogenesis; cdk7; cyclin dependent; dependent kinase ... See more keywords
SNHG1 lncRNA negatively regulates miR-199a-3p to enhance CDK7 expression and promote cell proliferation in prostate cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.169
Abstract: Long noncoding RNAs (lncRNAs) have been reported to play vital roles in the development of human cancers, but our understandings of most lncRNAs in cancers are still limited. Recently, accumlating evidences have showed that many… read more here.
Keywords: prostate; cdk7; mir 199a; prostate cancer ... See more keywords
A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022)
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DOI: 10.1080/13543776.2023.2195547
Abstract: ABSTRACT Introduction Cyclin-dependent kinase 7 (CDK7) is a member of the CDK family of serine/threonine protein kinases and participates in the regulation of the cell cycle and mRNA transcription. CDK7 is emerging as a possible… read more here.
Keywords: review; cdk7; dependent kinase; cyclin dependent ... See more keywords
Study of potent CDK7 inhibitor secondary metabolites from Tecomella undulata
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DOI: 10.1080/14786419.2021.2016748
Abstract: Abstract Chemical investigation of the petroleum ether extract of heartwood of Tecomella undulata led to the isolation of tectonaquinone B (1), 2-methylquinizarin (2) along with tecomaquinone I (3), lapachol (4), 2-isopropenylnaphtho[2,3-b]-furan-4,9-quinone (5), dehydro-α-lapachone (6), α-lapachone… read more here.
Keywords: cdk7 inhibitor; study potent; cdk7; tecomella undulata ... See more keywords
Targeting Cyclin-Dependent Kinase 7 - Association between CDK7 and pMED1 Expression in Prostate Cancer Tissue.
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DOI: 10.1093/carcin/bgac036
Abstract: Cyclin-dependent kinase (CDK) 7-mediated phosphorylation of Mediator-complex subunit 1 (MED1) enhances androgen receptor (AR) activity in prostate cancer (PCa). Hyperactive AR-signalling plays a key role for the development of castration resistance. Several CDK7 inhibitors are… read more here.
Keywords: cdk7; prostate; cyclin dependent; pca ... See more keywords
MBRS-26. CDK7 MEDIATED TRANSCRIPTIONAL PROCESSIVITY OF DNA REPAIR NETWORKS REGULATES SENSITIVITY TO RADIATION IN MYC DRIVEN MEDULLOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaa222.541
Abstract: Abstract Myc-driven Medulloblastoma remains a major therapeutic challenge due to frequent metastasis and a poor 5-year survival rate. Myc overexpression results in transcriptional dysregulation, proliferation, and survival of malignant cells. To identify therapeutic targets in… read more here.
Keywords: cdk7; dna repair; dna; myc driven ... See more keywords
ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment
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DOI: 10.1158/1535-7163.mct-16-0847
Abstract: Recent reports indicate that some cancer types are especially sensitive to transcription inhibition, suggesting that targeting the transcriptional machinery provides new approaches to cancer treatment. Cyclin-dependent kinase (CDK)7 is necessary for transcription, and acts by… read more here.
Keywords: orally bioavailable; transcription; cdk7; cancer treatment ... See more keywords
Abstract LB-317: Identification of a novel preclinical candidate for CDK7 inhibition
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DOI: 10.1158/1538-7445.am2017-lb-317
Abstract: Cyclin-dependent kinase 7 (CDK7) is an important constituent of the cellular transcriptional machinery, where it phosphorylates the C-terminal domain (CTD) of RNAP polymerase II (RNAPII). Because many tumor types are critically dependent on transcription for… read more here.
Keywords: cdk7; candidate; inhibition; cancer ... See more keywords
Abstract 4835: UD-017, a novel highly selective and orally active CDK7 inhibitor, shows a significant anticancer activity in patient-derived cancers
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DOI: 10.1158/1538-7445.am2018-4835
Abstract: Background: Cyclin dependent kinase 7 (CDK7) is an attractive target for anticancer drugs due to its dual roles, cell cycle regulation and gene transcription/RNA processing. We synthesized UD-017, a small-molecule, highly selective, orally active CDK7… read more here.
Keywords: highly selective; cdk7; cancer; cell ... See more keywords
CDK7 is a prognostic biomarker for non-small cell lung cancer
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DOI: 10.3389/fonc.2022.927140
Abstract: Aim Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related death globally despite promising progress of personalized therapy approaches. Cyclin-dependent kinase 7 (CDK7) is a kinase involved in transcription, overexpressed in a broad… read more here.
Keywords: non small; cdk7; expression; small cell ... See more keywords
Identification of CDK7 Inhibitors from Natural Sources Using Pharmacoinformatics and Molecular Dynamics Simulations
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DOI: 10.3390/biomedicines9091197
Abstract: The cyclin-dependent kinase 7 (CDK7) plays a crucial role in regulating the cell cycle and RNA polymerase-based transcription. Overexpression of this kinase is linked with various cancers in humans due to its dual involvement in… read more here.
Keywords: identification cdk7; cdk7; molecular dynamics; cdk7 inhibitors ... See more keywords