Study of potent CDK7 inhibitor secondary metabolites from Tecomella undulata
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2021.2016748
Abstract: Abstract Chemical investigation of the petroleum ether extract of heartwood of Tecomella undulata led to the isolation of tectonaquinone B (1), 2-methylquinizarin (2) along with tecomaquinone I (3), lapachol (4), 2-isopropenylnaphtho[2,3-b]-furan-4,9-quinone (5), dehydro-α-lapachone (6), α-lapachone… read more here.
Keywords: cdk7 inhibitor; study potent; cdk7; tecomella undulata ... See more keywords
G1 Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181
Sign Up to like & getrecommendations! Published in 2020 at "Cancers"
DOI: 10.3390/cancers12123845
Abstract: Simple Summary Chemotherapy resistance in human T-cell acute lymphoblastic leukemia (T-ALL), an aggressive neoplasm, results in poor prognosis despite advances in treatment modalities. Toward the identification of an effective alternative, in the present study, we… read more here.
Keywords: cell; inhibitor 181; jurkat; activity cdk7 ... See more keywords