Treg conversion dampens autoimmunity
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Drug Discovery"
DOI: 10.1038/d41573-019-00191-9
Abstract: Regulatory T (Treg) cells dampen immune responses. Augmenting Treg cells — either numerically or functionally — could therefore be therapeutic in autoimmune diseases. Work from the Sakaguchi and Narumiya labs now shows that small-molecule inhibitors… read more here.
Keywords: tconv cells; treg cells; treg; cdk8 cdk19 ... See more keywords
Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2458
Abstract: Enhancing production of the anti-inflammatory cytokine interleukin-10 (IL-10) is a promising strategy to suppress pathogenic inflammation. To identify new mechanisms regulating IL-10 production, we conducted a phenotypic screen for small molecules that enhance IL-10 secretion… read more here.
Keywords: identify cdk8; small molecule; cdk8 cdk19; cdk8 ... See more keywords
Molecular and in vivo Functions of the CDK8 and CDK19 Kinase Modules
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2018.00171
Abstract: CDK8 and its paralog, CDK19, collectively termed ‘Mediator Kinase,’ are cyclin-dependent kinases that have been implicated as key rheostats in cellular homeostasis and developmental programming. CDK8 and CDK19 are incorporated, in a mutually exclusive manner,… read more here.
Keywords: mediator kinase; mediator; kinase; cdk8 cdk19 ... See more keywords
Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection
Sign Up to like & getrecommendations! Published in 2020 at "Viruses"
DOI: 10.3390/v12060654
Abstract: Dengue virus infection is associated with the upregulation of metabolic pathways within infected cells. This effect is common to infection by a broad array of viruses. These metabolic changes, including increased glucose metabolism, oxidative phosphorylation… read more here.
Keywords: dengue virus; cyclin dependent; cdk8 cdk19; infection ... See more keywords