Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex.
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DOI: 10.1021/acs.jmedchem.2c02045
Abstract: The CDK8-cyclin C complex is an important anti-tumor target, but unlike CDK8, cyclin C remains undruggable. Modulators regulating cyclin C activity directly are still under development. Here, a series of hydrophobic tagging-based degraders of the… read more here.
Keywords: cdk8 cyclin; molecule; degrader; cyclin complex ... See more keywords