Discovery and Anti-Inflammatory Activity Evaluation of a Novel CDK8 Inhibitor through Upregulation of IL-10 for the Treatment of Inflammatory Bowel Disease In Vivo.
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DOI: 10.1021/acs.jmedchem.2c00356
Abstract: Increasing the anti-inflammatory cytokine interleukin-10 (IL-10) level is a promising strategy to suppress the progression of pathogenic inflammation including inflammatory bowel disease (IBD). Since cyclin-dependent kinase 8 (CDK8) inhibition can upregulate IL-10 abundance in activated… read more here.
Keywords: cdk8 inhibitor; inflammatory bowel; cdk8; anti inflammatory ... See more keywords
Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy.
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DOI: 10.1021/acs.jmedchem.2c01042
Abstract: CDK8 is a transcriptional cyclin-dependent kinase and considered as a potential target in colon cancer therapeutics. Here, a novel selective CDK8 inhibitor was identified against colon cancer in vivo. Specifically, based on the structural information… read more here.
Keywords: cdk8 inhibitor; cdk8; colon cancer; cancer ... See more keywords