CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors.
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DOI: 10.1016/j.ejmech.2018.11.076
Abstract: Cyclin-dependent kinases 8 (CDK8) regulates transcriptional process via associating with the mediator complex or phosphorylating transcription factors (TF). Overexpression of CDK8 has been observed in various cancers. It mediates aberrant activation of Wnt/β-catenin signaling pathway,… read more here.
Keywords: cdk8 inhibitors; cdk8 therapeutic; cdk8; cancers recent ... See more keywords