CDKAL1 Drives the Maintenance of Cancer Stem‐Like Cells by Assembling the eIF4F Translation Initiation Complex
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206542
Abstract: Cancer stem‐like cells (CSCs) have a unique translation mode, but little is understood about the process of elongation, especially the contribution of tRNA modifications to the maintenance of CSCs properties. Here, it is reported that,… read more here.
Keywords: cdkal1; eif4f translation; initiation complex; translation initiation ... See more keywords
The risk variant of CDKAL1 (rs7756992) impairs fasting glucose levels and insulin resistance improvements after a partial meal-replacement hypocaloric diet.
Sign Up to like & getrecommendations! Published in 2021 at "Endocrinologia, diabetes y nutricion"
DOI: 10.1016/j.endien.2020.08.017
Abstract: BACKGROUND The CDKAL1 (CDK5 Regulatory Subunit Associated Protein 1 Like 1) gene encodes cyclin-dependent kinase 5 (CDK5) regulatory subunit-associated proten1 like 1. This protein has been shown to contribute to the glucose-dependent regulation of insulin… read more here.
Keywords: glucose levels; fasting glucose; insulin resistance; cdkal1 ... See more keywords
Association Between CDKAL1, HHEX, CDKN2A/2B and IGF2BP2 Gene Polymorphisms and Susceptibility to Type 2 Diabetes in Uttarakhand, India
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s284998
Abstract: Introduction Current study aimed to find the association of genes polymorphism of CDKAL1, HHEX, CDKN2A/2B, and IGF2BP2 with type 2 diabetes (T2DM) in the population of Uttarakhand. Research Design and Methods Overall 469 persons comprising… read more here.
Keywords: t2dm cases; t2dm; cdkal1; association ... See more keywords