EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01029-x
Abstract: The EZH2 histone methyltransferase is required for B cells to form germinal centers (GC). Here we show that EZH2 mediates GC formation through repression of cyclin-dependent kinase inhibitor CDKN1A (p21Cip1). Deletion of Cdkn1a rescues the… read more here.
Keywords: cdkn1a; feedback loop; ezh2; germinal centre ... See more keywords
Abstract 1465: A SNAI2/CDKN1A pathway protects rhabdomyosarcoma tumors from radiation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1465
Abstract: Rhabdomyosarcoma (RMS) is tumor of the muscle and is the most common soft tissue cancer in children and teens, with approximately 400 to 500 new cases every year in the United States. There are two… read more here.
Keywords: snai2 cdkn1a; cdkn1a; snai2; tumors radiation ... See more keywords
Abstract 3724: RAI2 controls polycomb-mediated repression of CDKN1A by its interaction with CtBP1
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3724
Abstract: RAI2 has initially been identified as a metastasis-associated gene in breast cancer. Recently, we found that increased RAI2 protein in primary tumors predicts early biochemical relapse of prostate cancer patients. On the molecular level, RAI2… read more here.
Keywords: interaction; cdkn1a; rai2; ctbp1 ... See more keywords
LncRNA SNHG7 promotes the proliferation and inhibits apoptosis of renal cell cancer cells by downregulating CDKN1A.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201912_19661
Abstract: OBJECTIVE Recent studies have revealed that long non-coding RNAs (lncRNAs) have a crucial role in tumor progression. Renal cell cancer (RCC) is a common type of fatal gynecological cancer worldwide. This study aims to identify… read more here.
Keywords: cdkn1a; rcc; proliferation; cancer ... See more keywords
Weighted gene co-expression identification of CDKN1A as a hub inflammation gene following cardiopulmonary bypass in children with congenital heart disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Surgery"
DOI: 10.3389/fsurg.2022.963850
Abstract: Background Congenital heart disease (CHD) is the most common type of birth defect. Most patients with CHD require surgery, and cardiopulmonary bypass (CPB) is the most common surgery performed. Methods The present study utilized weighted… read more here.
Keywords: inflammation; cdkn1a; expression; analysis ... See more keywords
2,5-Hexanedione Affects Ovarian Granulosa Cells in Swine by Regulating the CDKN1A Gene: A Transcriptome Analysis
Sign Up to like & getrecommendations! Published in 2023 at "Veterinary Sciences"
DOI: 10.3390/vetsci10030201
Abstract: Simple Summary Porcine ovarian granulosa cells (pGCs), the main somatic cells in the follicular microenvironment, are close to oocytes. Under the action of various regulatory factors and exogenous substances, their abnormal proliferation, apoptosis and oxidative… read more here.
Keywords: cdkn1a; apoptosis; analysis; ovarian granulosa ... See more keywords
miR-93 enhances cell proliferation by directly targeting CDKN1A in nasopharyngeal carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2017.7492
Abstract: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy of the head and neck with the highest incidence rate in southern China. The aim of the present study was to understand the molecular mechanisms that underlie the… read more here.
Keywords: directly targeting; cdkn1a; cell proliferation; mir ... See more keywords